A randomized phase II study of acivicin and 4'deoxydoxorubicin in patients with hepatocellular carcinoma in an Eastern Cooperative Oncology Group study.

Abstract

We analyzed 56 of 75 previously untreated patients with hepatocellular carcinoma who entered on a prospectively randomized trial of acivicin versus 4'deoxydoxorubicin (esorubicin). At least one episode of severe toxicity was documented in 23% of the patients on acivicin and 45% of those on 4'deoxydoxorubicin. Two patients responded to 4'deoxydoxorubicin. One response was partial, lasting 58 weeks, and one was complete, lasting more than 4 years. The 90% confidence interval for response is 1-20%. In view of a 45% rate of severe or worse toxicity with 4'deoxydoxorubicin, this drug cannot be recommended as treatment. There were no responses on acivicin.

• Authors: G Falkson, A Cnaan, I W Simson, Y Dayal, H Falkson, T J Smith, D G Haller
• Journal: American journal of clinical oncology (Am J Clin Oncol) Vol. 13 Issue 6 Pg. 510-5 (Dec 1990) ISSN: 0277-3732 [Print] United States
• PMID: 2173394 (Publication Type: Clinical Trial, Journal Article, Multicenter Study, Randomized Controlled Trial, Research Support, U.S. Gov't, P.H.S.)

Chemical References

• Antibiotics, Antineoplastic
• Isoxazoles
• Doxorubicin
• acivicin
• esorubicin

Topics

• Antibiotics, Antineoplastic (administration & dosage, adverse effects, therapeutic use)
• Carcinoma, Hepatocellular (drug therapy, mortality)
• Doxorubicin (administration & dosage, adverse effects, analogs & derivatives, therapeutic use)
• Drug Administration Schedule
• Female
• Humans
• Isoxazoles (administration & dosage, adverse effects, therapeutic use)
• Liver Neoplasms (drug therapy, mortality)
• Male
• Prospective Studies
• Survival Rate