The role of Factor V Leiden in adult patients with venous thromboembolism: a meta-analysis of published studies from Turkey.

Abstract

Factor V Leiden (FVL) is the most common inherited risk factor for venous thromboembolism (VTE). The frequency of FVL in patients with VTE has been reported from different parts of Turkey. A meta-analysis was performed to estimate the risk of VTE associated with FVL in Turkish population. Published studies were retrieved from Pubmed and Science Citation Index/Expanded. We selected studies comparing the prevalence of FVL in patients with VTE with controls. The analysis was performed by the software comprehensive meta-analysis. The analysis consisted of 10 studies including 1202 patients with VTE and 1283 controls. The pooled frequency of FVL was significantly higher in patients with VTE (22.8%) than controls (7.6%). The pooled odds ratio (OR) was 3.4 (95% confidence interval [CI], 2.6-4.5). The study showed homogeneity (Q value, 9.955). No publication bias was observed in any comparison model. Our meta-analysis showed an association of FVL with VTE in Turkey.

• Authors: Aydan Eroglu, Durdu Sertkaya, Nejat Akar
• Journal: Clinical and applied thrombosis/hemostasis : official journal of the International Academy of Clinical and Applied Thrombosis/Hemostasis (Clin Appl Thromb Hemost) 2012 Jan-Feb Vol. 18 Issue 1 Pg. 40-4 ISSN: 1938-2723 [Electronic] United States
• PMID: 21733936 (Publication Type: Journal Article, Meta-Analysis)

Chemical References

• factor V Leiden
• Factor V

Topics

• Factor V
• Female
• Humans
• Male
• PubMed
• Risk Factors
• Thromboembolism (epidemiology, genetics, metabolism)
• Turkey (epidemiology)