Abstract | BACKGROUND: Role of caffeine consumption in chronic hepatitis B virus (HBV)-infected patients and the interaction with alcohol consumption is unclear. AIM: This study aimed to investigate the relationship between caffeine and alcohol consumption and liver stiffness in chronic HBV-infected patients. METHODS: Chronic HBV-infected patients who underwent transient elastography examination in 2006-2008 were studied. Advanced fibrosis was defined as liver stiffness > 9 kPa for patients with normal alanine aminotransferase (ALT) or > 12 kPa for those with elevated ALT according to previous validation study. Caffeine and alcohol consumption was recorded using a standardized questionnaire. Excessive alcohol intake was defined as 30 g/day in men and 20 g/day in women. RESULTS: The liver stiffness of 1045 patients who completed the questionnaire was 8.3 ± 6.2 kPa. Two hundred and sixteen (20.7%) patients had advanced fibrosis. Ninety-five (19.0%) patients who drank ≥ 1 cup of coffee had advanced fibrosis, compared with 121 (22.2%) patients who drank < 1 cup (P = 0.21). The amount of caffeine intake had positive correlation with the amount of alcohol intake (r(s) = 0.167, P < 0.001). Although 231 (22.1%) patients reported alcohol consumption, only 11 (1%) had excessive alcohol intake. The prevalence of advanced fibrosis among patients with mild to moderate alcohol intake (26, 18.8%) was comparable to that among non-drinkers (190, 21.0%) (P = 0.57). CONCLUSION:
Caffeine intake does not affect liver stiffness in chronic HBV-infected patients. Patients who drink coffee regularly tend to drink alcohol. Most chronic HBV-infected patients do not have excessive alcohol consumption. The prevalence of advanced fibrosis among mild to moderate alcohol drinkers was low in this population.
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Authors | Arlinking Ong, Vincent Wai-Sun Wong, Grace Lai-Hung Wong, Henry Lik-Yuen Chan |
Journal | Liver international : official journal of the International Association for the Study of the Liver
(Liver Int)
Vol. 31
Issue 7
Pg. 1047-53
(Aug 2011)
ISSN: 1478-3231 [Electronic] United States |
PMID | 21733095
(Publication Type: Journal Article)
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Copyright | © 2011 John Wiley & Sons A/S. |
Chemical References |
- Caffeine
- Alanine Transaminase
|
Topics |
- Adult
- Alanine Transaminase
(blood)
- Alcohol Drinking
- Body Mass Index
- Caffeine
(pharmacology)
- Elasticity Imaging Techniques
- Female
- Hepatitis B
(complications)
- Hong Kong
- Humans
- Liver
(pathology)
- Liver Cirrhosis
(etiology, pathology)
- Logistic Models
- Male
- Middle Aged
- Surveys and Questionnaires
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