Abstract | AIM:
Drug eluting stents (DES) are currently the gold standard for the treatment of significant coronary artery stenosis in high risk patients. In case of undeferrable non-cardiac surgery their use is still a challenge, due to the need of a prolonged dual antiplatelet therapy. We aimed to prospectively evaluate the efficacy and safety of the implantation of endothelial progenitor cells ( EPC) capture stent followed by a short dual anti-platelet therapy (DAT) period in a high risk population of patients undergoing undeferrable non-cardiac surgery. METHODS: RESULTS: Twenty-six patients underwent PCI and were enrolled, but only 20 underwent surgical intervention. Technical and procedural success rates were both 100%. No perioperative MACE was detected. After a mean long term follow-up of 15.4±10.3 months, 2 cases of cardiac death (10%), were recorded. No case of stent thrombosis was reported; no case of ischemia driven TLR was detected. The total MACE-free survival probability was 66.5%. CONCLUSION:
EPC capture stent implantation in high-risk patients requiring undeferrable non-cardiac surgery seems to allow early cand safe discontinuation of DAT, and may be an attractive alternative to conventional stents.
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Authors | P Scacciatella, M D'Amico, I Meynet, M Pennone, F Conrotto, G Amato, V Frisenda, E Pelloni, S Marra |
Journal | Minerva cardioangiologica
(Minerva Cardioangiol)
Vol. 59
Issue 5
Pg. 411-8
(Oct 2011)
ISSN: 0026-4725 [Print] Italy |
PMID | 21730938
(Publication Type: Journal Article)
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Chemical References |
- Platelet Aggregation Inhibitors
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Topics |
- Aged
- Angioplasty, Balloon, Coronary
- Endothelial Cells
- Female
- Humans
- Male
- Platelet Aggregation Inhibitors
(therapeutic use)
- Postoperative Complications
(epidemiology, etiology)
- Prospective Studies
- Risk Factors
- Stem Cells
- Stents
(adverse effects)
- Surgical Procedures, Operative
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