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Biomarkers of liver fibrosis: what lies beneath the receiver operating characteristic curve?

Abstract
Noninvasive biomarkers of liver fibrosis represent an intense area of research with the goals of improving patient care, disease stratification, and aiding the development of future antifibrotic therapies. Despite the rapid progress in recent years, there remain questions about how diagnostic studies are designed, statistical methods to account for spectrum bias, clinically relevant thresholds of fibrosis that should be delineated, how diagnostics can be improved, and strengthening the reference test to judge emerging biomarkers. This review discusses the current methods to address these issues and where further progress is needed.
AuthorsIndra Neil Guha, Robert P Myers, Keyur Patel, Jayant A Talwalkar
JournalHepatology (Baltimore, Md.) (Hepatology) Vol. 54 Issue 4 Pg. 1454-62 (Oct 2011) ISSN: 1527-3350 [Electronic] United States
PMID21725995 (Publication Type: Journal Article, Review)
CopyrightCopyright © 2011 American Association for the Study of Liver Diseases.
Chemical References
  • Biomarkers
Topics
  • Biomarkers (analysis)
  • Female
  • Humans
  • Liver Cirrhosis (blood, diagnosis)
  • Male
  • Predictive Value of Tests
  • ROC Curve
  • Severity of Illness Index
  • United Kingdom

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