Abstract | BACKGROUND AND AIMS: Although the exact pathogenetic factor in hepatic encephalopathy is still unknown, ammonia is considered to be the major cause of neurotoxicity. However, previous studies on the relationship between ammonia and the severity of hepatic encephalopathy have yielded variable results. Since unionized ammonia is the only form of ammonia that is able to freely spread through the blood-brain barrier and cause cerebral dysfunction, we tested the hypothesis that concentration of unionized ammonia is correlated with the severity of hepatic encephalopathy. METHODS: 156 patients with cirrhosis (74 with hepatic encephalopathy and 82 without) were enrolled, and underwent clinical examination and blood testing. Ammonia, pNH3 and pH determinations were repeated after two days of treatment. The differences in venous ammonia, pNH3, and pH among patients with and without encephalopathy were analyzed. RESULTS: CONCLUSION: This study supports that pH-dependant pNH3 and pH could be useful diagnostic and prognostic tools in cirrhotic patients with hepatic encephalopathy.
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Authors | Yong He, Guixing Li, Haolan Song, Tongxing Luo, Baoxiu Gao, Jin Xu |
Journal | Journal of gastrointestinal and liver diseases : JGLD
(J Gastrointestin Liver Dis)
Vol. 20
Issue 2
Pg. 169-74
(Jun 2011)
ISSN: 1842-1121 [Electronic] Romania |
PMID | 21725514
(Publication Type: Journal Article)
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Chemical References |
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Topics |
- Adult
- Aged
- Ammonia
(metabolism)
- Female
- Hepatic Encephalopathy
(metabolism, psychology)
- Humans
- Liver Cirrhosis
(metabolism)
- Liver Function Tests
- Male
- Mental Health
- Middle Aged
- Partial Pressure
- Sensitivity and Specificity
- Severity of Illness Index
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