Evaluation of a HTLV-1 subunit vaccine in prevention of experimental STLV-I infection in Macaca nemestrina.

Abstract

Pig-tailed macaques were vaccinated with a human T-cell lymphotropic virus type I (HTLV-I) subunit vaccine. Vaccinates and controls were challenged with simian T-cell lymphotropic virus type I (STLV-I)-infected cells. Vaccination yielded antibody responses to HTLV-I and STLV-I gag and env precursors. Controls developed HTLV-I and STLV-I antibody to gag and tax protein. Immunization produced syncytium inhibiting antibody and cellular cytotoxicity to virus-infected cells. Reverse transcriptase activity was present in control macaques only, implying that the subunit vaccine was protective against STLV-I infection.

• Authors: C S Dezzutti, D E Frazier, L J Lafrado, R G Olsen
• Journal: Journal of medical primatology (J Med Primatol) Vol. 19 Issue 3-4 Pg. 305-16 ( 1990) ISSN: 0047-2565 [Print] Denmark
• PMID: 2172541 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't, Research Support, U.S. Gov't, P.H.S.)

Chemical References

• Antibodies, Viral
• Antigens, Viral
• Gene Products, env
• Gene Products, gag
• HTLV-I Antibodies
• Viral Vaccines

Topics

• Animals
• Antibodies, Viral (biosynthesis)
• Antibody-Dependent Cell Cytotoxicity
• Antigens, Viral (immunology)
• Blotting, Western
• Cell Line
• Gene Products, env (immunology)
• Gene Products, gag (immunology)
• Giant Cells
• HTLV-I Antibodies (biosynthesis)
• Human T-lymphotropic virus 1 (immunology)
• Macaca nemestrina
• Retroviridae Infections (prevention & control)
• Simian T-lymphotropic virus 1 (immunology)
• Vaccination
• Viral Vaccines (immunology)