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Soluble lectin-like oxidized low-density lipoprotein receptor-1 levels in synovial fluid are correlated with disease severity of knee osteoarthritis.

AbstractOBJECTIVES:
This study was aimed to measure soluble lectin-like oxidized low-density lipoprotein receptor-1 (sLOX-1) levels in serum and synovial fluid (SF) of knee osteoarthritis (OA) patients and to investigate the correlation between sLOX-1 levels and the disease severity.
DESIGN AND METHODS:
Two hundred and sixteen OA patients and 83 healthy controls were enrolled in this study. All OA patients were scored for Kellgren-Lawrence (KL) grade (0-4). The sLOX-1 levels were measured by enzyme-linked immunosorbent assay (ELISA).
RESULTS:
In OA patients, the mean sLOX-1 levels in SF were markedly lower than those in paired serum samples (P<0.01). The SF sLOX-1 levels increased with higher KL grade (P<0.01) and were significantly correlated with disease severity (r = 0.324, P<0.01). SF sLOX-1 level was the independent factor for predicting the disease severity of OA (β: 0.281, 95%CI: 0.145-0.396).
CONCLUSIONS:
SF sLOX-1 levels were independently and positively associated with disease severity in knee OA.
AuthorsChun-Zhi Yang, Yi-Yuan Zhang, Ming Zheng
JournalClinical biochemistry (Clin Biochem) Vol. 44 Issue 13 Pg. 1094-1096 (Sep 2011) ISSN: 1873-2933 [Electronic] United States
PMID21723858 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
CopyrightCopyright © 2011 The Canadian Society of Clinical Chemists. Published by Elsevier Inc. All rights reserved.
Chemical References
  • OLR1 protein, human
  • Scavenger Receptors, Class E
Topics
  • Case-Control Studies
  • Enzyme-Linked Immunosorbent Assay
  • Humans
  • Osteoarthritis, Knee (diagnosis, pathology)
  • Scavenger Receptors, Class E (analysis)
  • Severity of Illness Index
  • Solubility
  • Synovial Fluid (chemistry)

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