Abstract | OBJECTIVES: DESIGN AND METHODS: Two hundred and sixteen OA patients and 83 healthy controls were enrolled in this study. All OA patients were scored for Kellgren-Lawrence (KL) grade (0-4). The sLOX-1 levels were measured by enzyme-linked immunosorbent assay (ELISA). RESULTS: In OA patients, the mean sLOX-1 levels in SF were markedly lower than those in paired serum samples (P<0.01). The SF sLOX-1 levels increased with higher KL grade (P<0.01) and were significantly correlated with disease severity (r = 0.324, P<0.01). SF sLOX-1 level was the independent factor for predicting the disease severity of OA (β: 0.281, 95%CI: 0.145-0.396). CONCLUSIONS: SF sLOX-1 levels were independently and positively associated with disease severity in knee OA.
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Authors | Chun-Zhi Yang, Yi-Yuan Zhang, Ming Zheng |
Journal | Clinical biochemistry
(Clin Biochem)
Vol. 44
Issue 13
Pg. 1094-1096
(Sep 2011)
ISSN: 1873-2933 [Electronic] United States |
PMID | 21723858
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Copyright | Copyright © 2011 The Canadian Society of Clinical Chemists. Published by Elsevier Inc. All rights reserved. |
Chemical References |
- OLR1 protein, human
- Scavenger Receptors, Class E
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Topics |
- Case-Control Studies
- Enzyme-Linked Immunosorbent Assay
- Humans
- Osteoarthritis, Knee
(diagnosis, pathology)
- Scavenger Receptors, Class E
(analysis)
- Severity of Illness Index
- Solubility
- Synovial Fluid
(chemistry)
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