Abstract | BACKGROUND AND AIMS: METHODS: RESULTS: PON-1 activity was decreased (p=0.023), whereas SAA levels were increased (p=0.042) in MetS subjects, coinciding with higher hs-CRP levels and HOMA(ir) values. Multiple linear regression analysis revealed that age- and gender-adjusted PON-1 activity was related inversely to SAA (β=-0.256, p=0.020) after adjustment for MetS, or alternatively for hs-CRP and HOMA(ir) (β=-0.271, p=0.049). CONCLUSIONS: Decreased serum PON-1 activity in MetS may in part be attributable to higher SAA levels. We suggest that higher SAA levels contribute to impaired HDL anti-oxidative function in MetS via an effect on PON-1 regulation.
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Authors | Paul Jan Willem Herman Kappelle, Johan Bijzet, Bouke Pier Hazenberg, Robin Pieter Frank Dullaart |
Journal | Archives of medical research
(Arch Med Res)
Vol. 42
Issue 3
Pg. 219-25
(Apr 2011)
ISSN: 1873-5487 [Electronic] United States |
PMID | 21722818
(Publication Type: Journal Article)
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Copyright | Copyright © 2011 IMSS. Published by Elsevier Inc. All rights reserved. |
Chemical References |
- Lipoproteins, HDL
- Serum Amyloid A Protein
- C-Reactive Protein
- Cholesterol
- Aryldialkylphosphatase
- PON1 protein, human
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Topics |
- Aged
- Aryldialkylphosphatase
(blood)
- C-Reactive Protein
(metabolism)
- Case-Control Studies
- Cholesterol
(blood)
- Female
- Humans
- Linear Models
- Lipoproteins, HDL
(blood)
- Male
- Metabolic Syndrome
(blood)
- Middle Aged
- Serum Amyloid A Protein
(metabolism)
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