HOMEPRODUCTSCOMPANYCONTACTFAQResearchDictionaryPharmaSign Up FREE or Login

Animal model of implant capsular contracture: effects of chitosan.

AbstractBACKGROUND:
The mechanism(s) responsible for breast capsular contracture (CC) remain unknown, but inflammatory pathways play a role. Various molecules have been attached to implant shells in the hope of modifying or preventing CC. The intrinsic antibacterial and antifungal activities of chitosan and related oligochitosan molecules lend themselves well to the study of the infectious hypothesis; chitosan's ability to bind to growth factors, its hemostatic action, and its ability to activate macrophages, cause cytokine stimulation, and increase the production of transforming growth factor (TGF)-β1 allow study of the hypertrophic scar hypothesis.
OBJECTIVE:
The authors perform a comprehensive evaluation, in a rabbit model, of the relationship between CC and histological, microbiological, and immunological characteristics in the presence of a chitooligosaccharide (COS) mixture and a low molecular weight chitosan (LMWC).
METHODS:
Eleven adult New Zealand rabbits were each implanted with three silicone implants: a control implant, one impregnated with COS, and one impregnated with LMWC. At four-week sacrifice, microdialysates were obtained in the capsule-implant interfaces for tumor necrosis factor alpha (TNF-α) and interleukin-8 (IL-8) level assessment. Histological and microbiological analyses were performed.
RESULTS:
Baker grade III/IV contractures were observed in the LMWC group, with thick capsules, dense connective tissue, and decreased IL-8 levels (p < .05) compared to control and COS groups. Capsule tissue bacterial types and microdialysate TNF-α levels were similar among all groups.
CONCLUSIONS:
Chitosan-associated silicone implantation in a rabbit model resulted in Baker grade III/IV CC. This preclinical study may provide a model to test various mechanistic hypotheses of breast capsule formation and subsequent CC.
AuthorsMarisa Marques, Spencer A Brown, Pedro Rodrigues-Pereira, M Natália, D S Cordeiro, Aliuska Morales-Helguera, Luís Cobrado, Lara Queirós, Rui Freitas, João Fernandes, Inês Correia-Sá, Acácio Gonçalves Rodrigues, José Amarante
JournalAesthetic surgery journal (Aesthet Surg J) Vol. 31 Issue 5 Pg. 540-50 (Jul 2011) ISSN: 1527-330X [Electronic] England
PMID21719867 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
Chemical References
  • Interleukin-8
  • Oligosaccharides
  • Silicone Gels
  • Transforming Growth Factor beta1
  • Tumor Necrosis Factor-alpha
  • Chitosan
Topics
  • Animals
  • Breast Implants (adverse effects)
  • Chitosan (pharmacology)
  • Disease Models, Animal
  • Female
  • Implant Capsular Contracture (etiology, microbiology, pathology)
  • Interleukin-8 (metabolism)
  • Microdialysis
  • Oligosaccharides (chemistry)
  • Rabbits
  • Silicone Gels
  • Transforming Growth Factor beta1 (metabolism)
  • Tumor Necrosis Factor-alpha (metabolism)

Join CureHunter, for free Research Interface BASIC access!

Take advantage of free CureHunter research engine access to explore the best drug and treatment options for any disease. Find out why thousands of doctors, pharma researchers and patient activists around the world use CureHunter every day.
Realize the full power of the drug-disease research graph!


Choose Username:
Email:
Password:
Verify Password:
Enter Code Shown: