A rare cause of pulmonary infiltrates one should be aware of: a case of daptomycin-induced acute eosinophilic pneumonia.

Abstract

We report a 69-year-old patient who developed fever and dyspnea 3 weeks after the initiation of daptomycin therapy for spondylodiscitis with lumbar epidural and bilateral psoas abscesses due to ampicillin- and high-level-gentamicin-resistant Enterococcus faecium. There was profound hypoxia and the chest X-ray showed extensive patchy infiltrates bilaterally. A bronchoalveolar lavage revealed 30% eosinophils and results of microbiological studies were normal. Daptomycin-induced eosinophilic pneumonia was diagnosed and the patient rapidly improved after the discontinuation of daptomycin and a brief course of prednisone. Increased attention must be paid to this rare but serious side effect of daptomycin.

• Authors: C Rether, A Conen, M Grossenbacher, W C Albrich
• Journal: Infection (Infection) Vol. 39 Issue 6 Pg. 583-5 (Dec 2011) ISSN: 1439-0973 [Electronic] Germany
• PMID: 21717147 (Publication Type: Case Reports, Journal Article)

Chemical References

• Anti-Bacterial Agents
• Daptomycin

Topics

• Abscess (drug therapy)
• Aged
• Anti-Bacterial Agents (administration & dosage, adverse effects)
• Bronchoalveolar Lavage Fluid (cytology)
• Daptomycin (administration & dosage, adverse effects)
• Discitis (complications, drug therapy)
• Enterococcus faecium
• Gram-Positive Bacterial Infections (drug therapy, microbiology)
• Humans
• Lung (pathology)
• Male
• Pulmonary Eosinophilia (chemically induced, diagnosis, pathology)
• Radiography, Thoracic