Abstract | UNLABELLED:
Plasmapheresis is an effective treatment modality in several immunological kidney diseases. It is also indicated in certain neurological and hematological abnormalities, and some other diseases. AIMS: In this study the indications and outcomes of the plasma exchange treatments performed in the Plasmapheresis Unit of the authors during the last 12 years are summarized, and the findings are compared to those published in the literature. The procedure, mechanisms of action and adverse effects are also briefly discussed. METHODS: RESULTS:
Plasmapheresis, completed as part of combined immunosuppressive treatment, resulted in remarkable improvements in patients with anti-cytoplasmic antibody-associated vasculitis. Out of the 91 patients, 54 needed urgent dialysis on admission, and renal replacement therapy could be discontinued in 44% of them. Renal functions in those patients who did not need dialysis also improved significantly, and pulmonary hemorrhage ceased in all affected subjects. Survival of the patients with anti-glomerular basement membrane diseases was 100%. The treatment significantly improved the renal function in rapidly progressive lupus nephritis, and all the 5 cases of lupus cerebritis were successfully cured. The results showed less effectiveness in therapy resistant focal segmental glomerular sclerosis and in rapidly progressing immunocomplex glomerulonephritis. Plasmapheresis proved to be very efficient in cases with the primary hemolytic uremic syndrome, and each patient with HELLP syndrome recovered completely. The outcome of those with multiple myeloma was less favorable, although hyperviscosity was rapidly and effectively decreased by the plasmapheresis. The treatment improved the conditions of almost all patients with neurological diseases. DISCUSSION: According to these findings plasmapheresis treatment, introduced by proper indications, effectively improves the outcomes of several diseases. Early diagnosis and immediate introduction of the plasmapheresis are very important - in conjunction with the appropriate therapy of the underlying diseases.
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Authors | Agnes Haris, József Arányi, Henrik Braunitzer, Eva Kálmán, Zoltán Merán, Mariann Soltész, Kálmán Polner |
Journal | Orvosi hetilap
(Orv Hetil)
Vol. 152
Issue 28
Pg. 1110-9
(Jul 10 2011)
ISSN: 0030-6002 [Print] Hungary |
Vernacular Title | A plazmaferézis szerepe immunológiai etiológiájú vesebetegségekben. Tapasztalataink 1050 elvégzett feréziskezelés kapcsán. |
PMID | 21712172
(Publication Type: English Abstract, Journal Article)
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Chemical References |
- Antibodies, Antineutrophil Cytoplasmic
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Topics |
- Adult
- Aged
- Aged, 80 and over
- Anti-Glomerular Basement Membrane Disease
(complications, therapy)
- Antibodies, Antineutrophil Cytoplasmic
(blood)
- Female
- Glomerulonephritis
(complications, therapy)
- HELLP Syndrome
(immunology)
- Hemolytic-Uremic Syndrome
(complications, therapy)
- Humans
- Kidney Diseases
(immunology, therapy)
- Lupus Erythematosus, Systemic
(complications)
- Male
- Middle Aged
- Multiple Myeloma
(complications)
- Nervous System Diseases
(complications)
- Plasma Exchange
(adverse effects, methods)
- Plasmapheresis
(adverse effects, methods)
- Pregnancy
- Pregnancy Complications
(immunology, therapy)
- Treatment Outcome
- Vasculitis
(complications)
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