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Tailored imaging of islet cell tumors of the pancreas amidst increasing options.

Abstract
Pancreatic islet cell tumors are neuroendocrine tumors, which can produce hormones and can arise as part of multiple endocrine neoplasia type 1 or von-Hippel-Lindau-disease, two genetically well-defined hereditary cancer syndromes. Currently, technical innovation improves conventional and specific molecular imaging techniques. To organize the heterogeneous results described for the imaging of these tumors, we distinguished three indications (1) imaging of a patient with hormone hypersecretion, (2) search for a pancreatic primary in case of proven neuroendocrine cancer of unknown primary, and (3) screening of asymptomatic mutation carriers. We searched for publications on imaging of islet cell tumors between 1995 and January 2010 and defined a Level of Evidence (LOE) for the applicability of each technique. For each technique, data were analyzed in a Forest plot and arranged per imaging indication and tumor subtype. LOEs are weak for all imaging techniques. Analyses indicate a prominent role for endoscopic ultrasound for all three indications.
AuthorsHelle-Brit Fiebrich, Sophie J van Asselt, Adrienne H Brouwers, Hendrik M van Dullemen, Milan E J Pijl, Philip H Elsinga, Thera P Links, Elisabeth G E de Vries
JournalCritical reviews in oncology/hematology (Crit Rev Oncol Hematol) Vol. 82 Issue 2 Pg. 213-26 (May 2012) ISSN: 1879-0461 [Electronic] Netherlands
PMID21704529 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't, Review)
CopyrightCopyright © 2011 Elsevier Ireland Ltd. All rights reserved.
Topics
  • Humans
  • Islets of Langerhans (pathology)
  • Magnetic Resonance Imaging
  • Pancreatic Neoplasms (diagnostic imaging, pathology)
  • Positron-Emission Tomography
  • Tomography, Emission-Computed, Single-Photon
  • Tomography, X-Ray Computed

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