Abstract | BACKGROUND: METHODS: RESULTS: Compared with those in the sham-treated group, lung edema and MPO activity, expressions of iNOS, TNF-α and IL-6, and plasma peroxynitrite were significantly increased in the vehicle-treated group. Significant attenuations of these parameters were found in the magnolol-treated or HTS-treated animals. Combined treatment of magnolol and HTS further suppressed the lung edema, iNOS, and TNF-α expressions, and plasma peroxynitrite, compared with the results of a single treatment of magnolol or HTS. CONCLUSIONS: Compared with single-agent use, co-administration of magnolol and HTS further decreases iNOS expression and plasma peroxynitrite as well as the degree of lung injury from MISR. These results may provide another treatment measure for post-injury immunomodulation.
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Authors | Hsin-Chin Shih, Mu-Shun Huang, Chen-Hsen Lee |
Journal | The Journal of surgical research
(J Surg Res)
Vol. 175
Issue 2
Pg. 305-11
(Jun 15 2012)
ISSN: 1095-8673 [Electronic] United States |
PMID | 21704335
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Copyright | Copyright © 2012 Elsevier Inc. All rights reserved. |
Chemical References |
- Antioxidants
- Biphenyl Compounds
- Interleukin-6
- Lignans
- Peroxides
- Saline Solution, Hypertonic
- Tumor Necrosis Factor-alpha
- magnolol
- Peroxynitrous Acid
- Nitric Oxide Synthase Type II
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Topics |
- Animals
- Antioxidants
(therapeutic use)
- Biphenyl Compounds
(therapeutic use)
- Interleukin-6
(blood)
- Lignans
(therapeutic use)
- Lung
(metabolism, pathology)
- Male
- Mesentery
(blood supply)
- Mice
- Mice, Inbred C3H
- Models, Animal
- Nitric Oxide Synthase Type II
(metabolism)
- Peroxides
(metabolism)
- Peroxynitrous Acid
(blood)
- Pulmonary Edema
(blood, etiology, prevention & control)
- Regional Blood Flow
(physiology)
- Reperfusion Injury
(complications)
- Saline Solution, Hypertonic
(therapeutic use)
- Tumor Necrosis Factor-alpha
(blood)
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