Abstract | INTRODUCTION: The purpose of the present study was to evaluate the feasibility of delayed gadolinium-enhanced magnetic resonance imaging of cartilage (dGEMRIC) in the detection of cartilage changes versus morphologic imaging in the long-term course of Legg-Calvé-Perthes disease (LCPD). METHODS: A total of 31 hips in 26 patients (mean age, 30.0years; range, 18-54years) who were diagnosed with LCPD in childhood were included. Twenty-one radiographically normal contralateral hips served as controls. dGEMRIC indices of femoral and acetabular cartilage in the weight-bearing zone. Cartilage morphology was classified on radial PD-weighted images according to the modified Outerbridge classification. RESULTS: Mean dGEMRIC values of cartilage were significantly lower in hips after LCPD than in the radiographically normal contralateral hips (513±100 ms vs. 579±103 ms; P=0.026). In 24 out of 31 LCPD hips and in 4 out of 21 radiographically normal contralateral hips, morphological cartilage changes were noted. Analysis of variance analysis revealed a significant influence of Outerbridge grading on decreased T1-values (P=0.031). CONCLUSION: Our results suggest that dGEMRIC at 1.5 T is suitable to assess cartilage quality changes in the long-term follow-up after LCPD. The evaluation of biochemical cartilage quality with dGEMRIC may provide additional information about early cartilage changes occurring without visible alterations of cartilage morphology.
|
Authors | Arne Holstein, Christoph Zilkens, Bernd Bittersohl, Marcus Jäger, Tanja Haamberg, Tallal C Mamisch, Rotem S Lanzman, Patric Kröpil, Dirk Blondin, Rüdiger Krauspe, Gerald Antoch, Günther Fürst, Falk Miese |
Journal | Journal of medical imaging and radiation oncology
(J Med Imaging Radiat Oncol)
Vol. 55
Issue 3
Pg. 259-65
(Jun 2011)
ISSN: 1754-9485 [Electronic] Australia |
PMID | 21696558
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
|
Copyright | © 2011 The Authors. Journal of Medical Imaging and Radiation Oncology © 2011 The Royal Australian and New Zealand College of Radiologists. |
Chemical References |
- Contrast Media
- Gadolinium DTPA
|
Topics |
- Adolescent
- Adult
- Cartilage, Articular
(pathology)
- Contrast Media
- Female
- Gadolinium DTPA
- Humans
- Legg-Calve-Perthes Disease
(pathology)
- Magnetic Resonance Imaging
- Male
- Middle Aged
- Young Adult
|