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Delayed gadolinium-enhanced MRI of cartilage (dGEMRIC) and morphologic MRI of cartilage in the long-term follow-up after Legg-Calvé-Perthes disease (LCPD).

AbstractINTRODUCTION:
The purpose of the present study was to evaluate the feasibility of delayed gadolinium-enhanced magnetic resonance imaging of cartilage (dGEMRIC) in the detection of cartilage changes versus morphologic imaging in the long-term course of Legg-Calvé-Perthes disease (LCPD).
METHODS:
A total of 31 hips in 26 patients (mean age, 30.0years; range, 18-54years) who were diagnosed with LCPD in childhood were included. Twenty-one radiographically normal contralateral hips served as controls. dGEMRIC indices of femoral and acetabular cartilage in the weight-bearing zone. Cartilage morphology was classified on radial PD-weighted images according to the modified Outerbridge classification.
RESULTS:
Mean dGEMRIC values of cartilage were significantly lower in hips after LCPD than in the radiographically normal contralateral hips (513±100 ms vs. 579±103 ms; P=0.026). In 24 out of 31 LCPD hips and in 4 out of 21 radiographically normal contralateral hips, morphological cartilage changes were noted. Analysis of variance analysis revealed a significant influence of Outerbridge grading on decreased T1-values (P=0.031).
CONCLUSION:
Our results suggest that dGEMRIC at 1.5 T is suitable to assess cartilage quality changes in the long-term follow-up after LCPD. The evaluation of biochemical cartilage quality with dGEMRIC may provide additional information about early cartilage changes occurring without visible alterations of cartilage morphology.
AuthorsArne Holstein, Christoph Zilkens, Bernd Bittersohl, Marcus Jäger, Tanja Haamberg, Tallal C Mamisch, Rotem S Lanzman, Patric Kröpil, Dirk Blondin, Rüdiger Krauspe, Gerald Antoch, Günther Fürst, Falk Miese
JournalJournal of medical imaging and radiation oncology (J Med Imaging Radiat Oncol) Vol. 55 Issue 3 Pg. 259-65 (Jun 2011) ISSN: 1754-9485 [Electronic] Australia
PMID21696558 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
Copyright© 2011 The Authors. Journal of Medical Imaging and Radiation Oncology © 2011 The Royal Australian and New Zealand College of Radiologists.
Chemical References
  • Contrast Media
  • Gadolinium DTPA
Topics
  • Adolescent
  • Adult
  • Cartilage, Articular (pathology)
  • Contrast Media
  • Female
  • Gadolinium DTPA
  • Humans
  • Legg-Calve-Perthes Disease (pathology)
  • Magnetic Resonance Imaging
  • Male
  • Middle Aged
  • Young Adult

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