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Variant G57E of mannose binding lectin associated with protection against tuberculosis caused by Mycobacterium africanum but not by M. tuberculosis.

Abstract
Structural variants of the Mannose Binding Lectin (MBL) cause quantitative and qualitative functional deficiencies, which are associated with various patterns of susceptibility to infectious diseases and other disorders. We determined genetic MBL variants in 2010 Ghanaian patients with pulmonary tuberculosis (TB) and 2346 controls and characterized the mycobacterial isolates of the patients. Assuming a recessive mode of inheritance, we found a protective association between TB and the MBL2 G57E variant (odds ratio 0.60, confidence interval 0.4-0.9, P 0.008) and the corresponding LYQC haplotype (P(corrected) 0.007) which applied, however, only to TB caused by M. africanum but not to TB caused by M. tuberculosis. In vitro, M. africanum isolates bound recombinant human MBL more efficiently than did isolates of M. tuberculosis. We conclude that MBL binding may facilitate the uptake of M. africanum by macrophages, thereby promoting infection and that selection by TB may have favoured the spread of functional MBL deficiencies in regions endemic for M. africanum.
AuthorsThorsten Thye, Stefan Niemann, Kerstin Walter, Susanne Homolka, Christopher D Intemann, Margaret Amanua Chinbuah, Anthony Enimil, John Gyapong, Ivy Osei, Ellis Owusu-Dabo, Sabine Rüsch-Gerdes, Rolf D Horstmann, Stefan Ehlers, Christian G Meyer
JournalPloS one (PLoS One) Vol. 6 Issue 6 Pg. e20908 ( 2011) ISSN: 1932-6203 [Electronic] United States
PMID21695215 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
Chemical References
  • Mannose-Binding Lectin
Topics
  • Case-Control Studies
  • Genetic Predisposition to Disease (genetics)
  • Genotype
  • HIV (pathogenicity)
  • Humans
  • Mannose-Binding Lectin (genetics, metabolism)
  • Mycobacterium tuberculosis (classification, genetics, pathogenicity)
  • Polymorphism, Single Nucleotide
  • Species Specificity
  • Tuberculosis, Pulmonary (genetics, microbiology, virology)

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