Abstract | BACKGROUND: METHODS: RESULTS: We found frataxin content to be correlated in peripheral blood mononuclear cells and skeletal muscle in drug-naive patients with Friedreich ataxia. The correlation of frataxin content in both compartments remained significant after 8 weeks of treatment. Skeletal-muscle frataxin values correlated with ataxia using the Scale for the Assessment and Rating of Ataxia score. CONCLUSIONS:
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Authors | Wolfgang Nachbauer, Julia Wanschitz, Hannes Steinkellner, Andreas Eigentler, Brigitte Sturm, Kurt Hufler, Barbara Scheiber-Mojdehkar, Werner Poewe, Markus Reindl, Sylvia Boesch |
Journal | Movement disorders : official journal of the Movement Disorder Society
(Mov Disord)
Vol. 26
Issue 10
Pg. 1935-8
(Aug 15 2011)
ISSN: 1531-8257 [Electronic] United States |
PMID | 21692115
(Publication Type: Clinical Trial, Journal Article, Research Support, Non-U.S. Gov't)
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Copyright | Copyright © 2011 Movement Disorder Society. |
Chemical References |
- Biomarkers
- Iron-Binding Proteins
- frataxin
- Erythropoietin
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Topics |
- Adult
- Biomarkers
(metabolism)
- Biopsy
- Disability Evaluation
- Erythropoietin
(therapeutic use)
- Female
- Friedreich Ataxia
(blood, drug therapy, pathology)
- Humans
- Iron-Binding Proteins
(metabolism)
- Male
- Middle Aged
- Muscle, Skeletal
(metabolism)
- Statistics as Topic
- Time Factors
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