Vitreous vascular endothelial growth factor concentrations in proliferative diabetic retinopathy versus proliferative vitreoretinopathy.

Abstract

PURPOSE:

To assess vitreous vascular endothelial growth factor (VEGF) concentrations in proliferative diabetic retinopathy (PDR) in comparison to proliferative vitreoretinopathy (PVR).

PATIENTS AND METHODS:

Vitreous samples were collected from 69 eyes of 69 patients with traumatic lens dislocation (n = 10), grade B PVR with rhegmatogenous retinal detachment (n = 13), grade C PVR with rhegmatogenous retinal detachment (n = 14), PDR with vitreous hemorrhage (n = 18), and PDR with vitreous hemorrhage and tractional retinal detachment (n = 14). Vitreous fluid samples were obtained at vitrectomy, and the levels of VEGF were measured by enzyme-linked immunosorbent assay.

RESULTS:

The mean vitreous level of VEGF was 15.14 ± 5.22 pg/ml in eyes with grade B PVR, 99.15 ± 38.58 pg/ml in eyes with grade C PVR, 4,534.01 ± 1,193.28 pg/ml in eyes with vitreous hemorrhage secondary to PDR, 5,157.29 ± 969.44 pg/ml in eyes with vitreous hemorrhage and tractional retinal detachment secondary to PDR, and 16.19 ± 5.76 pg/ml in eyes of the control group with traumatic lens dislocation. Vitreous VEGF concentrations were significantly higher in the patients with grade C PVR, PDR with vitreous hemorrhage and PDR with vitreous hemorrhage and tractional retinal detachment in comparison to the control patients (p < 0.05). A significant alteration was not observed in patients with grade B PVR (p = 0.55).

CONCLUSIONS:

Vitreous VEGF concentrations are increased in PDR and grade C PVR. The high VEGF concentrations could suggest a possible effect of VEGF on advanced PVR.

• Authors: Mehmet Citirik, Emrah Utku Kabatas, Cosar Batman, Kadir Okhan Akin, Naciye Kabatas
• Journal: Ophthalmic research (Ophthalmic Res) Vol. 47 Issue 1 Pg. 7-12 ( 2012) ISSN: 1423-0259 [Electronic] Switzerland
• PMID: 21691136 (Publication Type: Comparative Study, Journal Article)
• Copyright: Copyright © 2011 S. Karger AG, Basel.

Chemical References

• VEGFA protein, human
• Vascular Endothelial Growth Factor A

Topics

• Adolescent
• Adult
• Aged
• Diabetic Retinopathy (metabolism)
• Enzyme-Linked Immunosorbent Assay
• Female
• Humans
• Male
• Middle Aged
• Retinal Detachment (metabolism)
• Vascular Endothelial Growth Factor A (metabolism)
• Vitrectomy
• Vitreoretinopathy, Proliferative (metabolism)
• Vitreous Body (metabolism)
• Vitreous Hemorrhage (metabolism)
• Young Adult