Abstract | BACKGROUND: HYPOTHESIS: Dogs on CCNU receiving Denamarin have lower alanine aminotransferase (ALT) activity than dogs not receiving Denamarin. Dogs on Denamarin are less likely to require treatment delay because of hepatopathy and are more likely to complete their prescribed course of CCNU. ANIMALS: METHODS: Dogs were prospectively randomized to receive either concurrent Denamarin during CCNU chemotherapy or to receive CCNU alone. Liver-specific laboratory tests were run before each dose of CCNU. RESULTS: CONCLUSIONS: Increased liver enzyme activity occurs commonly in dogs receiving CCNU chemotherapy. These results support the use of concurrent Denamarin to minimize increased liver enzyme activity in dogs receiving CCNU chemotherapy. Denamarin treatment also increases the likelihood of dogs completing a prescribed CCNU course.
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Authors | K A Skorupski, G M Hammond, A M Irish, M S Kent, T A Guerrero, C O Rodriguez, D W Griffin |
Journal | Journal of veterinary internal medicine
(J Vet Intern Med)
2011 Jul-Aug
Vol. 25
Issue 4
Pg. 838-45
ISSN: 1939-1676 [Electronic] United States |
PMID | 21689156
(Publication Type: Clinical Trial, Journal Article, Randomized Controlled Trial, Research Support, Non-U.S. Gov't)
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Copyright | Copyright © 2011 by the American College of Veterinary Internal Medicine. |
Chemical References |
- Silymarin
- Silybin
- Lomustine
- S-Adenosylmethionine
- Cholesterol
- Aspartate Aminotransferases
- Alanine Transaminase
- Alkaline Phosphatase
- Bilirubin
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Topics |
- Alanine Transaminase
(blood)
- Alkaline Phosphatase
(blood)
- Animals
- Aspartate Aminotransferases
(blood)
- Bilirubin
(blood)
- Chemical and Drug Induced Liver Injury
(blood, pathology, prevention & control, veterinary)
- Cholesterol
(blood)
- Dog Diseases
(blood, chemically induced, prevention & control)
- Dogs
- Female
- Lomustine
(adverse effects, therapeutic use)
- Male
- Neoplasms
(blood, drug therapy, veterinary)
- Prospective Studies
- S-Adenosylmethionine
(administration & dosage)
- Silybin
- Silymarin
(administration & dosage)
- Statistics, Nonparametric
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