Treatment of Buerger disease (thromboangiitis obliterans) with bosentan: a case report.

Abstract

Buerger disease (thromboangiitis obliterans) is a non-atherosclerotic segmental inflammatory disease strongly associated with tobacco use, and it affects small and medium-sized blood vessels in the upper and lower extremities. The only known treatment for this disease is complete discontinuation of tobacco use. This report describes the case history of a woman with Buerger disease treated with the oral dual endothelin receptor antagonist bosentan. It is believed that this is the first description in the literature of this use for bosentan.

• Authors: Joaquin De Haro, Aurora Florez, Jose Luis Fernandez, Francisco Acin
• Journal: BMJ case reports (BMJ Case Rep) Vol. 2009 ( 2009) ISSN: 1757-790X [Electronic] England
• PMID: 21686681 (Publication Type: Journal Article)