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Orofacial granulomatosis associated with hypersensitivity to dental amalgam.

Abstract
Orofacial granulomatosis is a clinicopathologic entity characterized by chronic swelling of the lip and possible soft tissues in the orofacial region owing to granulomatous inflammation of unknown cause. We present 3 cases of orofacial granulomatosis associated with allergic contact dermatitis to dental materials. Previous treatment with corticosteroids did not have any therapeutic effect. Patch testing revealed a positive reaction to several allergens, including dental amalgam and mercury in 2 cases. A lymphocyte transformation test modified for metals was used to evaluate lymphocyte reactivity. After the removal of the suspected allergens, all patients experienced recovery within 1 month, with the exception of the lip swelling, which gradually subsided over several months.
AuthorsMilan Tomka, Alena Machovcová, Daniela Pelclová, Jitka Petanová, Monika Arenbergerová, Jarmila Procházková
JournalOral surgery, oral medicine, oral pathology, oral radiology, and endodontics (Oral Surg Oral Med Oral Pathol Oral Radiol Endod) Vol. 112 Issue 3 Pg. 335-41 (Sep 2011) ISSN: 1528-395X [Electronic] United States
PMID21684771 (Publication Type: Case Reports, Journal Article, Research Support, Non-U.S. Gov't)
CopyrightCopyright © 2011 Mosby, Inc. All rights reserved.
Chemical References
  • Dental Amalgam
  • Mercury
Topics
  • Adult
  • Dental Amalgam (adverse effects)
  • Female
  • Granulomatosis, Orofacial (chemically induced, pathology, therapy)
  • Humans
  • Hypersensitivity, Delayed (etiology, pathology, therapy)
  • Lip Diseases (chemically induced, pathology, therapy)
  • Mercury (adverse effects)
  • Middle Aged
  • Patch Tests
  • Treatment Outcome
  • Young Adult

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