Abstract | BACKGROUND: MATERIALS AND METHODS: RESULTS: A total of 29 penile intraepithelial neoplasias (100%) and 69 of 115 (60%) invasive cancers contained HPV high-risk genotypes with a single HPV high-risk genotype (80% HPV16, 6% HPV33, 2% HPV45 and HPV18, 1% HPV73). Multiple HPV high-risk genotypes were identified in 4% with and in 5% without HPV16/18. p16 overexpression correlated in all but 1 case of HPV high-risk 45 cancer. No p16 overexpression and HPV genotype was found in 6 differentiated penile intraepithelial neoplasias and 46 of 115 (40%) invasive cancers, 30% of which were pT2/pT3 cancers. For 35 cancers, peritumoral tissue was available for analysis. Advanced lichen sclerosus was identified in 26, lichen planus in 9, and differentiated penile intraepithelial neoplasia in 18 carcinomas. Dense T-cell-dominant lymphocytic infiltrates were identified in 22 of 46 carcinomas and in 3 of 6 differentiated penile intraepithelial neoplasias, with 6 of 13 analyzed carcinomas/penile intraepithelial neoplasias showing a monoclonal rearrangement of the T-cell receptor γ locus. CONCLUSIONS:
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Authors | Sebastian Mannweiler, Stephan Sygulla, Christine Beham-Schmid, Yas Razmara, Karl Pummer, Sigrid Regauer |
Journal | The American journal of surgical pathology
(Am J Surg Pathol)
Vol. 35
Issue 7
Pg. 998-1006
(Jul 2011)
ISSN: 1532-0979 [Electronic] United States |
PMID | 21681144
(Publication Type: Journal Article)
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Chemical References |
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Topics |
- Adolescent
- Adult
- Aged
- Aged, 80 and over
- Austria
(epidemiology)
- Carcinoma in Situ
(epidemiology, pathology, virology)
- Carcinoma, Squamous Cell
(epidemiology, pathology, virology)
- Comorbidity
- DNA, Viral
(analysis)
- Humans
- Lichen Planus
(epidemiology, pathology, virology)
- Lichen Sclerosus et Atrophicus
(epidemiology, pathology, virology)
- Male
- Middle Aged
- Papillomaviridae
(genetics, isolation & purification)
- Papillomavirus Infections
(complications, epidemiology, pathology)
- Penile Neoplasms
(epidemiology, pathology, virology)
- Risk Factors
- Young Adult
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