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[The antiviral activity of amiksin and its effect on the interferon status in hepatitis in mice].

Abstract
A single administration of amixin followed by oral infection with mouse hepatitis virus provided protection of 40%-50% animals for 72 hours and normalized the interferon status. In parallel with decreasing level of virus-induced endogenous interferon the interferon-inhibiting activity of lymphocytes of the infected animals increased and approached normal levels.
AuthorsS S Grigorian, A M Ivanova, F I Ershov
JournalVoprosy virusologii (Vopr Virusol) 1990 Mar-Apr Vol. 35 Issue 2 Pg. 138-40 ISSN: 0507-4088 [Print] Russia (Federation)
Vernacular TitleProtivovirusnaia aktivnost' amiksina i ego vliianie na interferonovyÄ­ status pri gepatitie mysheÄ­.
PMID2167565 (Publication Type: Comparative Study, English Abstract, Journal Article)
Chemical References
  • Antiviral Agents
  • Fluorenes
  • Interferon Inducers
  • Interferon Type I
  • Interferon-gamma
  • Tilorone
Topics
  • Animals
  • Antiviral Agents (therapeutic use)
  • Drug Evaluation, Preclinical
  • Fluorenes (therapeutic use)
  • Hepatitis, Viral, Animal (blood, drug therapy)
  • Interferon Inducers (therapeutic use)
  • Interferon Type I (blood)
  • Interferon-gamma (blood)
  • Male
  • Mice
  • Murine hepatitis virus
  • Tilorone (analogs & derivatives, therapeutic use)
  • Time Factors

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