Abstract | OBJECTIVE: METHODS: Patients records with MPH from 2003 to 2006 were reviewed. Data collected were demographics, APACHE II scores, International Normalized Ratio (INR), fibrinogen level, blood product administration, rates of pulmonary embolism (PE), deep vein thrombosis (DVT), myocardial infarction (MI), hysterectomy, and mortality. Continuous variables within groups were analyzed with paired t-test, and independent t-test between groups. Categorical variables were compared via chi2 or Fishers Exact test and significance was denoted by a p < or = 0.05. RESULTS: Twenty-seven patients with MPH were investigated, eight received rFVIIa (study group) and 19 did not (control group). All patients received a massive transfusion, six units of packed red blood cells (pRBCs), via a massive transfusion protocol. The study group's mean APACHE II score 25.8 +/- 8.5, predicted mortality of 56.2 percent, was higher than control, p = 0.009. An increase in transfused units of cryoprecipitate, p < 0.001, pRBCs, p = 0.004, decrease in INR, p < 0.001, and length of stay in the high risk obstetrical unit, p = 0.019, existed in the study group. Hysterectomy was required in 85.7 percent of the study group. No patients developed a DVT, PE, or MI and all survived. CONCLUSIONS:
Recombinant Factor VIIa use in MPH is safe, improves coagulopathy, was not effective in decreasing blood product transfusion requirements, and may contribute to an improved predicted mortality.
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Authors | Michael Kalina, Glen Tinkoff, Gerard Fulda |
Journal | Delaware medical journal
(Del Med J)
Vol. 83
Issue 4
Pg. 109-13
(Apr 2011)
ISSN: 0011-7781 [Print] United States |
PMID | 21675158
(Publication Type: Journal Article)
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Chemical References |
- Recombinant Proteins
- recombinant FVIIa
- Factor VIIa
|
Topics |
- Adult
- Blood Transfusion
- Erythrocyte Transfusion
- Factor VIIa
(therapeutic use)
- Female
- Humans
- Hysterectomy
- Length of Stay
(statistics & numerical data)
- Postpartum Hemorrhage
(drug therapy, therapy)
- Pregnancy
- Pregnancy Complications, Hematologic
(drug therapy)
- Recombinant Proteins
(therapeutic use)
- Retrospective Studies
- Treatment Outcome
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