Abstract | CONTEXT: OBJECTIVE: DESIGN, SETTING, AND PARTICIPANTS: MAIN OUTCOME MEASURES: RESULTS: At study enrollment, the mean (SD) estimated glomerular filtration rate (GFR) was 42.8 (13.5) mL/min/1.73 m(2), and the median FGF-23 level was 145.5 RU/mL (interquartile range [IQR], 96-239 reference unit [RU]/mL). During a median follow-up of 3.5 years (IQR, 2.5-4.4 years), 266 participants died (20.3/1000 person-years) and 410 reached end-stage renal disease (33.0/1000 person-years). In adjusted analyses, higher levels of FGF-23 were independently associated with a greater risk of death (hazard ratio [HR], per SD of natural log-transformed FGF-23, 1.5; 95% confidence interval [CI], 1.3-1.7). Mortality risk increased by quartile of FGF-23: the HR was 1.3 (95% CI, 0.8-2.2) for the second quartile, 2.0 (95% CI, 1.2-3.3) for the third quartile, and 3.0 (95% CI, 1.8-5.1) for the fourth quartile. Elevated fibroblast growth factor 23 was independently associated with significantly higher risk of end-stage renal disease among participants with an estimated GFR between 30 and 44 mL/min/1.73 m(2) (HR, 1.3 per SD of FGF-23 natural log-transformed FGF-23; 95% CI, 1.04-1.6) and 45 mL/min/1.73 m(2) or higher (HR, 1.7; 95% CI, 1.1-2.4), but not less than 30 mL/min/1.73 m(2). CONCLUSION:
|
Authors | Tamara Isakova, Huiliang Xie, Wei Yang, Dawei Xie, Amanda Hyre Anderson, Julia Scialla, Patricia Wahl, Orlando M Gutiérrez, Susan Steigerwalt, Jiang He, Stanley Schwartz, Joan Lo, Akinlolu Ojo, James Sondheimer, Chi-yuan Hsu, James Lash, Mary Leonard, John W Kusek, Harold I Feldman, Myles Wolf, Chronic Renal Insufficiency Cohort (CRIC) Study Group |
Journal | JAMA
(JAMA)
Vol. 305
Issue 23
Pg. 2432-9
(Jun 15 2011)
ISSN: 1538-3598 [Electronic] United States |
PMID | 21673295
(Publication Type: Journal Article, Research Support, N.I.H., Extramural)
|
Chemical References |
- Biomarkers
- FGF23 protein, human
- Fibroblast Growth Factors
- Fibroblast Growth Factor-23
|
Topics |
- Aged
- Biomarkers
(blood)
- Chronic Disease
- Disease Progression
- Female
- Fibroblast Growth Factor-23
- Fibroblast Growth Factors
(blood)
- Glomerular Filtration Rate
- Humans
- Kidney Diseases
(blood, mortality)
- Kidney Failure, Chronic
(blood, mortality)
- Male
- Middle Aged
- Outcome Assessment, Health Care
- Prognosis
- Prospective Studies
- Risk Factors
|
|
Join CureHunter, for free Research Interface BASIC access!
Take advantage of free CureHunter research engine access to explore the best drug and treatment options for any disease.
Find out why thousands of doctors, pharma researchers and patient activists
around the world use CureHunter every day.
Realize the full power of the drug-disease research graph!
|