Abstract | OBJECTIVE: CASE SUMMARY: DISCUSSION:
Dipyridamole-associated hypotension has been reported in a number of case series and registries. Detailed case descriptions, however, are not available in the literature to permit understanding of the mechanism of shock following hypotension resulting from dipyridamole myocardial scintigraphy. Our case is exceptional in that echocardiography results support a diagnosis of hypovolemic (rather than cardiogenic) shock. To our knowledge, this is the first case of severe (most likely noncardiogenic) pulmonary edema associated with intravenous infusion of dipyridamole. An objective causality assessment suggested that this patient's cardiopulmonary collapse was probably related to dipyridamole. CONCLUSIONS: While hypotension has been previously associated with intravenous use of dipyridamole, ours is the first report to suggest a noncardiogenic mechanism for shock. To our knowledge, this is the first reported case of noncardiogenic pulmonary edema following dipyridamole infusion.
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Authors | Maria Dioverti, Robert Fishman, Robert Moskowitz, Sixto A Arias, Sumi Nair, Priyanka Lall, Adam E Schussheim, Stuart Zarich, Constantine Manthous |
Journal | The Annals of pharmacotherapy
(Ann Pharmacother)
Vol. 45
Issue 7-8
Pg. e42
(Jul 2011)
ISSN: 1542-6270 [Electronic] United States |
PMID | 21672887
(Publication Type: Case Reports, Journal Article)
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Chemical References |
- Vasodilator Agents
- Dipyridamole
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Topics |
- Aged
- Dipyridamole
(administration & dosage, adverse effects)
- Female
- Humans
- Infusions, Intravenous
- Myocardial Perfusion Imaging
(adverse effects)
- Pulmonary Edema
(etiology, therapy)
- Shock
(chemically induced, physiopathology, therapy)
- Treatment Outcome
- Vasodilator Agents
(administration & dosage, adverse effects)
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