Abstract | BACKGROUND: METHODS: Seventeen patients scheduled to cholecystectomy or inguinal herniorraphy were randomized and given 474 ml and 237 ml of water (CO group) or a drink containing CHO and milk whey protein (CHO-P group) respectively, 6 and 3 hours before operation. Blood samples were collected before surgery and 24 hours afterwards for biochemical assays. The endpoints of the study were the insulin resistance (IR), the prognostic inflammatory and nutritional index (PINI) and the C-reactive protein (CRP)/ albumin ratio. A 5% level for significance was established. RESULTS: There were no anesthetic or postoperative complications. The post-operative IR was lower in the CHO-P group when compared with the CO group (2.75 ± 0.72 vs 5.74 ± 1.16; p = 0.03). There was no difference between the two groups in relation to the PINI. The CHO-P group showed a decrease in the both CRP elevation and CRP/ albumin ratio (p < 0.05). The proportion of patients who showed CRP/ albumin ratio considered normal was significantly greater (p < 0.05) in the CHO-P group (87.5%) than in the CO group (33.3%). CONCLUSIONS: TRIAL REGISTRATION: ClinicalTrial.gov NCT01354249.
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Authors | Francine Perrone, Antônio C da-Silva-Filho, Isa F Adôrno, Nadia T Anabuki, Fernando S Leal, Tariane Colombo, Benedito D da Silva, Diana B Dock-Nascimento, Aderson Damião, José E de Aguilar-Nascimento |
Journal | Nutrition journal
(Nutr J)
Vol. 10
Pg. 66
(Jun 13 2011)
ISSN: 1475-2891 [Electronic] England |
PMID | 21668975
(Publication Type: Journal Article, Randomized Controlled Trial, Research Support, Non-U.S. Gov't)
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Chemical References |
- Albumins
- Carbohydrates
- Milk Proteins
- Whey Proteins
- C-Reactive Protein
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Topics |
- Acute-Phase Reaction
(drug therapy, pathology)
- Adult
- Albumins
(administration & dosage, analysis)
- C-Reactive Protein
(metabolism)
- Carbohydrates
(administration & dosage)
- Double-Blind Method
- Fasting
- Female
- Humans
- Insulin Resistance
- Male
- Middle Aged
- Milk Proteins
(administration & dosage, analysis)
- Perioperative Care
- Whey Proteins
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