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Mercaptoacetyltriglycine-3 renogram is not superior to estimated glomerular filtration rate measurement for the prediction of long-term renal function after nephrectomy.

AbstractOBJECTIVE:
To evaluate the clinical usefulness of effective renal plasma flow (ERPF) measured using preoperative mercaptoacetyltriglycine-3 (MAG3) renogram for the prediction of chronic renal insufficiency after nephrectomy.
METHODS:
A total of 47 patients underwent preoperative MAG3 renal scintigraphy and subsequent unilateral nephrectomy. Correlations between the 5-year postoperative estimated glomerular filtration rate (eGFR) and the preoperative ERPF of the contralateral kidney (cERPF), ERPF of the diseased kidney (dERPF), total ERPF (tERPF), cERPF to dERPF ratio, serum creatinine (sCr) level, eGFR, as well as the influence of preoperative comorbidities (diabetes, hypertension) on the postoperative eGFR, were evaluated with both univariate and multivariate analyses.
RESULTS:
Multiple linear regression analysis showed that preoperative cERPF significantly correlated with postoperative eGFR. However, a much stronger correlation was observed between the preoperative and postoperative eGFR. Multiple logistic regression analysis showed that only preoperative eGFR was a significant predicator of the development of advanced-stage chronic kidney disease (CKD).
CONCLUSIONS:
Preoperative MAG3 renogram is not superior to eGFR measurement as a prognostic indicator of long-term renal function after unilateral nephrectomy.
AuthorsHiroshi Kanamaru, Masakazu Yamamoto, Kanji Nagahama, Yusuke Yagihashi, Keiji Kato, Tomoyuki Oida, Toru Kannno, Noriyasu Takao, Yusuke Shimizu, Yasumasa Shichiri
JournalInternational journal of urology : official journal of the Japanese Urological Association (Int J Urol) Vol. 18 Issue 8 Pg. 570-4 (Aug 2011) ISSN: 1442-2042 [Electronic] Australia
PMID21668508 (Publication Type: Comparative Study, Journal Article)
Copyright© 2011 The Japanese Urological Association.
Chemical References
  • Radiopharmaceuticals
  • Technetium Tc 99m Mertiatide
Topics
  • Adult
  • Aged
  • Aged, 80 and over
  • Female
  • Glomerular Filtration Rate
  • Humans
  • Kidney Function Tests
  • Male
  • Middle Aged
  • Nephrectomy
  • Radioisotope Renography
  • Radiopharmaceuticals
  • Technetium Tc 99m Mertiatide
  • Time Factors

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