Intranasal flunisolide treatment in patients with non-allergic rhinitis.

Non-allergic rhinitis (NAR) is a heterogeneous disease, characterized by nasal hyperreactivity and inflammation. Its treatment is still debated, intranasal corticosteroids may be an option. The present study is aimed at evaluating the effect of the use of intranasal flunisolide in patients with NAR, considering both clinical and cytological parameters. Sixty patients were treated with intranasal flunisolide (30) or saline solution (30) for 8 weeks. Symptom severity, turbinate size, and inflammatory cell counts were assessed, before and after treatment. Intranasal flunisolide induced a significant reduction of symptoms, turbinate size, and cellular infiltrate. Thus, intranasal flunisolide might be a therapeutic option for NAR.
AuthorsA Varricchio, M Capasso, A De Lucia, F Avvisati, A M Varricchio, G Bettoncelli, G Ciprandi
JournalInternational journal of immunopathology and pharmacology (Int J Immunopathol Pharmacol) 2011 Apr-Jun Vol. 24 Issue 2 Pg. 401-9 ISSN: 0394-6320 [Print] Italy
PMID21658314 (Publication Type: Journal Article, Multicenter Study, Randomized Controlled Trial)
Chemical References
  • Anti-Inflammatory Agents
  • Fluocinolone Acetonide
  • flunisolide
  • Administration, Inhalation
  • Adult
  • Anti-Inflammatory Agents (administration & dosage)
  • Female
  • Fluocinolone Acetonide (administration & dosage, analogs & derivatives)
  • Humans
  • Italy
  • Male
  • Middle Aged
  • Nebulizers and Vaporizers
  • Rhinitis (diagnosis, drug therapy, immunology)
  • Severity of Illness Index
  • Single-Blind Method
  • Time Factors
  • Treatment Outcome
  • Young Adult

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