Systematic evaluation of exertional hyperthermia in children and adolescents with hypohidrotic ectodermal dysplasia: an observational study.

To evaluate exertional overheating and the impact of physical exercise on individuals with hypohidrotic ectodermal dysplasia (HED) and to assess protective effects of cooling devices, 13 boys and male adolescents with X-linked HED (XLHED) and age-matched healthy male controls were studied during standardized exercise on a bicycle ergometer at ambient temperatures of 25 and 30°C, without cooling and with evaporative skin cooling devices at 30°C. Body core temperature during and after exercise, heart rate, performance, endurance, and serum lactate were investigated. XLHED subjects experienced a significantly greater rise in body temperature after cycling than healthy controls, and their body temperature remained elevated longer. Maximum heart rates and lactate values did not differ significantly between XLHED and control groups. Application of skin cooling devices led to a clinically relevant attenuation of exertional hyperthermia in XLHED patients, and a previous tendency toward lower performance disappeared. This first systematic study of the effects of physical exercise on HED patients demonstrates a rapid and lasting body temperature increase in XLHED subjects after cycling, posing them at risk of exercise-induced hyperthermia. External evaporative skin cooling attenuates exertional overheating in HED patients and may facilitate their participation in athletic activities and professional life.
AuthorsJohanna E Hammersen, Valentin Neukam, Kai-Dietrich Nüsken, Holm Schneider
JournalPediatric research (Pediatr Res) Vol. 70 Issue 3 Pg. 297-301 (Sep 2011) ISSN: 1530-0447 [Electronic] United States
PMID21646941 (Publication Type: Clinical Trial, Journal Article, Research Support, Non-U.S. Gov't)
  • Adolescent
  • Body Temperature (physiology)
  • Body Temperature Regulation (physiology)
  • Child
  • Ectodermal Dysplasia 1, Anhidrotic (physiopathology)
  • Exercise (physiology)
  • Exercise Test
  • Fever (physiopathology)
  • Heart Rate (physiology)
  • Humans
  • Male
  • Sports

Join CureHunter, for free Research Interface BASIC access!

Take advantage of free CureHunter research engine access to explore the best drug and treatment options for any disease. Find out why thousands of doctors, pharma researchers and patient activists around the world use CureHunter every day.
Realize the full power of the drug-disease research network!

Choose Username:
Verify Password: