Abstract |
Functionalized fullerenes represent a new class of photosensitizer (PS) that is being investigated for photodynamic therapy ( PDT) of various diseases, including cancer. We tested the hypothesis that fullerenes could be used to mediate PDT of intraperitoneal (IP) carcinomatosis in a mouse model. In humans this form of cancer responds poorly to standard treatment and manifests as a thin covering of tumor nodules on intestines and on other abdominal organs. We used a colon adenocarcinoma cell line (CT26) stably expressing luciferase to allow monitoring of IP tumor burden in BALB/c mice by noninvasive real-time optical imaging using a sensitive low-light camera. IP injection of a preparation of N-methylpyrrolidinium- fullerene formulated in Cremophor-EL micelles, followed by white-light illumination delivered through the peritoneal wall (after creation of a skin flap), produced a statistically significant reduction in bioluminescence and a survival advantage in mice. FROM THE CLINICAL EDITOR:
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Authors | Pawel Mroz, Yumin Xia, Daisuke Asanuma, Aaron Konopko, Timur Zhiyentayev, Ying-Ying Huang, Sulbha K Sharma, Tianhong Dai, Usman J Khan, Tim Wharton, Michael R Hamblin |
Journal | Nanomedicine : nanotechnology, biology, and medicine
(Nanomedicine)
Vol. 7
Issue 6
Pg. 965-74
(Dec 2011)
ISSN: 1549-9642 [Electronic] United States |
PMID | 21645643
(Publication Type: Journal Article, Research Support, N.I.H., Extramural, Research Support, Non-U.S. Gov't, Research Support, U.S. Gov't, Non-P.H.S.)
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Copyright | Copyright © 2011 Elsevier Inc. All rights reserved. |
Chemical References |
- Fullerenes
- Micelles
- Photosensitizing Agents
- Pyrrolidines
- N-methylpyrrolidine
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Topics |
- Abdomen
(pathology)
- Adenocarcinoma
(drug therapy, pathology)
- Animals
- Cell Line, Tumor
- Colonic Neoplasms
(drug therapy, pathology)
- Fullerenes
(administration & dosage, chemistry, therapeutic use)
- Humans
- Injections, Intraperitoneal
- Male
- Mice
- Mice, Inbred BALB C
- Micelles
- Peritoneum
(drug effects, pathology)
- Photochemotherapy
(methods)
- Photosensitizing Agents
(administration & dosage, chemistry, therapeutic use)
- Pyrrolidines
(administration & dosage, chemistry, therapeutic use)
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