HOMEPRODUCTSCOMPANYCONTACTFAQResearchDictionaryPharmaSign Up FREE or Login

AKR1B10 expression is associated with less aggressive hepatocellular carcinoma: a clinicopathological study of 168 cases.

AbstractBACKGROUND/AIMS:
The detoxification enzyme AKR1B10, a member of the aldo-keto reductase superfamily, is discussed as a new biomarker candidate for hepatocellular carcinoma (HCC). Only rare clinicopathological data on AKRB1B10 in HCC exist. This retrospective study determines the diagnostic and prognostic relevance of AKR1B10 expression in HCC and its relationship to a series of clinicopathological parameters including underlying aetiological factors.
METHODS:
A series of 168 patients with HCCs treated either by surgical resection (n=92) or liver transplantation (n=76) were investigated after construction of a tissue micro-array. Immunohistochemically confirmed AKR1B10 expression was correlated with clinicopathologically relevant parameters as well as proliferative activity (indicated by Ki-67 immunostaining) and apoptosis (terminal deoxyribonucleotide transferase-mediated dUTP nick-end labelling).
RESULTS:
AKR1B10 overexpression is significantly associated with lower pT-classification (P=0.030) and highly statistically associated with an underlying viral hepatitis (P<0.001) and the presence of cirrhosis (P<0.001). In addition, loss of AKR1B10 expression correlates with increased proliferative activity (Ki-67, P=0.001). Kaplan-Meier survival analysis of the resection group reveals a poorer prognosis in patients with AKR1B10-negative HCCs compared with patients with strongly positive HCCs (P=0.046).
CONCLUSIONS:
This study confirms and expands data on the expression of AKR1B10 in HCC, suggesting that this enzyme is a valuable novel biomarker candidate for staging of HCC, especially in patients with underlying virus hepatitis or cirrhosis, and may present a new therapeutic target for multimodal therapy concepts. We confirm its prognostic value and conclude that high expression of AKR1B10 reflects a less aggressive tumour behaviour.
AuthorsKlaus J Schmitz, Georgios C Sotiropoulos, Hideo A Baba, Kurt W Schmid, Doris Müller, Andreas Paul, Thomas Auer, Gabriele Gamerith, Judith Loeffler-Ragg
JournalLiver international : official journal of the International Association for the Study of the Liver (Liver Int) Vol. 31 Issue 6 Pg. 810-6 (Jul 2011) ISSN: 1478-3231 [Electronic] United States
PMID21645211 (Publication Type: Journal Article)
Copyright© 2011 John Wiley & Sons A/S.
Chemical References
  • Biomarkers, Tumor
  • AKR1B10 protein, human
  • Aldo-Keto Reductases
  • Aldehyde Reductase
Topics
  • Aldehyde Reductase (analysis)
  • Aldo-Keto Reductases
  • Apoptosis
  • Biomarkers, Tumor (analysis)
  • Carcinoma, Hepatocellular (enzymology, mortality, pathology, surgery)
  • Catheter Ablation
  • Cell Proliferation
  • Chemoembolization, Therapeutic
  • Chi-Square Distribution
  • Disease-Free Survival
  • Female
  • Hepatectomy
  • Humans
  • Immunohistochemistry
  • Kaplan-Meier Estimate
  • Liver Neoplasms (enzymology, mortality, pathology, surgery)
  • Liver Transplantation
  • Male
  • Neoplasm Staging
  • Proportional Hazards Models
  • Retrospective Studies
  • Risk Assessment
  • Risk Factors
  • Survival Analysis
  • Time Factors
  • Tissue Array Analysis
  • Treatment Outcome

Join CureHunter, for free Research Interface BASIC access!

Take advantage of free CureHunter research engine access to explore the best drug and treatment options for any disease. Find out why thousands of doctors, pharma researchers and patient activists around the world use CureHunter every day.
Realize the full power of the drug-disease research graph!


Choose Username:
Email:
Password:
Verify Password:
Enter Code Shown: