Abstract | OBJECTIVES: DESIGN AND METHODS: Forty treatment-naive Gaucher patients were studied. 27/40 GP were put on ERT and monitored every 6 months. RESULTS: The baseline median values of Chito, TACP, ACE and ferritin were highly elevated in GP: 10216 nmol/mL/h, 26.1 U/L, 253 U/L, 515 μg/L, and 555 μg/L, respectively. The only significant difference between mild and moderate GP subgroups is observed for Chito activity (p=0.0116). During ERT, Chito showed the steepest decrease in regard to TACP and ACE, mainly within the first year (71.4%). CONCLUSIONS: Among these biomarkers, Chito proved to be the most useful biomarker for diagnosing GD and monitoring the ERT.
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Authors | Zorica Sumarac, Nada Suvajdžić, Svetlana Ignjatović, Nada Majkić-Singh, Dragana Janić, Milan Petakov, Maja Dorđević, Mirjana Mitrović, Marijana Dajak, Milka Golubović, Predrag Rodić |
Journal | Clinical biochemistry
(Clin Biochem)
Vol. 44
Issue 12
Pg. 950-4
(Aug 2011)
ISSN: 1873-2933 [Electronic] United States |
PMID | 21640089
(Publication Type: Controlled Clinical Trial, Journal Article, Research Support, Non-U.S. Gov't)
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Copyright | Copyright © 2011 The Canadian Society of Clinical Chemists. Published by Elsevier Inc. All rights reserved. |
Chemical References |
- Biomarkers
- Ferritins
- Acid Phosphatase
- Hexosaminidases
- chitotriosidase
- Glucosylceramidase
- Peptidyl-Dipeptidase A
- imiglucerase
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Topics |
- Acid Phosphatase
(blood)
- Adolescent
- Adult
- Aged
- Aged, 80 and over
- Biomarkers
(metabolism)
- Case-Control Studies
- Child
- Enzyme Replacement Therapy
- Female
- Ferritins
(blood)
- Gaucher Disease
(diagnosis, drug therapy, metabolism)
- Glucosylceramidase
(therapeutic use)
- Hexosaminidases
(blood)
- Humans
- Male
- Middle Aged
- Peptidyl-Dipeptidase A
(blood)
- Serbia
- Severity of Illness Index
- Young Adult
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