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[Early biliary complications following liver transplantation].

AbstractINTRODUCTION:
Biliary complications (BC) after liver transplantation (LTx) are serious problems with an incidence rate of 6-35%. There are two types of BC, early and late. Early BC is observed for 30 days post LTx or during the entire period of the patient's first hospital stay after LTx. The main causes of early BC are ischemia of the biliary tree (the bile duct of the transplanted liver is supplied only from the right hepatic artery descendingly; the supply from the gastroduodenal artery is lacking) as well as implementation of the biliary anastomosis surgical technique. Treatment of BC is administered by a surgeon, a gastroenterologist and a radiologist.
AIM:
To evaluate early biliary complications after LTx
PATIENTS AND METHODS:
We reviewed patients with early BC after LTx from 4/2004 - 12/2009. We defined early BC as a complication that is present during the first 30 days post LTx or during the entire period of the patient's first hospital stay after LTx.
RESULTS:
We performed 384 LTx during the above-mentioned period. We carried out reconstruction of the biliary tree in the form of a choledochocholedochostomy (CDD) in 312 cases and in the form of a choledochojejunostomy (CDJ) in 72 cases. Sixty-eight patients had early BC (17.7%), 25 patients experienced biliary leak (6.5%), 40 patients had anastomotic stenosis (10.4%) and 3 patients (0.8%) experienced both complications (biliary leak and stenosis). Most complications were eliminated by ERCP with a papilosfincterotomy, a balloon dilatation of stenosis, and a biliary stent implant with repeated stent replacements (45 cases in total- all patients with biliary stenosis). Twenty-two patients were reoperated on (16x CDJ, 3x re-CDD, 2x suture of aberrant bile duct, 1x suture common bile duct) and 1 patient was treated by percutaneous transhepatic bilary drainage (PTD). The mortality rate was zero.
CONCLUSION:
BC after LTx continue to pose a serious surgical problem. The treatment of choice when dealing with BC is ERCP, which has more than a 70% success rate. If ERCP or PTD are not successful, or when biliary peritonitis is present, we perform a reanastomosis of the bile duct. The combined effort of the surgeon, gastroenterologist and radiologist is the most important factor for successful treatment. The incidence of BC after LTx at IKEM is similar to that of treatment centers all over the world.
AuthorsM Kucera, M Adamec, M Oliverius, L Janousek, M Kocík, J Spicák, P Stirand, P Drastich, J Peregrin, P Trunecka
JournalRozhledy v chirurgii : mesicnik Ceskoslovenske chirurgicke spolecnosti (Rozhl Chir) Vol. 90 Issue 2 Pg. 117-21 (Feb 2011) ISSN: 0035-9351 [Print] Czech Republic
Vernacular TitleCasné biliární komplikace po transplantaci jater.
PMID21638850 (Publication Type: English Abstract, Journal Article)
Topics
  • Anastomotic Leak (diagnosis, etiology, surgery)
  • Biliary Tract Diseases (diagnosis, etiology, surgery)
  • Cholangiopancreatography, Endoscopic Retrograde
  • Cholestasis (diagnosis, etiology, surgery)
  • Humans
  • Liver Transplantation (adverse effects)

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