Immuno-cell therapy with antecedent surgery has superior actuarial survival to immuno-cell therapy without antecedent surgery for advanced cancers.

Abstract

BACKGROUND:

Immuno-cell therapy using activated lymphocytes (ALs) and/or dendritic cells (DCs) is considered one of the less toxic supportive therapies compared with conventional chemotherapy and radiotherapy, especially for the treatment for advanced cancers. To improve the efficacy of immuno-cell therapy for such cancer, clinical data were analyzed in this preliminary study.

PATIENTS AND METHODS:

The clinical data of 38 consecutive patients with advanced cancer who underwent at least one course of treatment with ALs and/or matured DCs, with or without antecedent surgery or additional conventional chemotherapy and/or radiotherapy, were evaluated.

RESULTS:

Of the 23 patients who received surgery before immuno-cell therapy, 2 (8.7%) showed a complete response (CR) and 15 (65%) showed a partial response (PR) or prolonged stable disease (SD). Of the 15 remaining patients who did not undergo antecedent surgery, there was no CR but 7 (46%) showed PR or prolonged SD. Actuarial survival is one of the important indices for the evaluation of anticancer therapies that present longer durable efficacy of immunotherapy compared with conventional anticancer chemotherapy and radiotherapy, and actuarial survival analysis revealed that immuno-cell therapy with antecedent surgery afforded significantly longer survival than immuno-cell therapy without antecedent surgery (P < 0.001).

CONCLUSION:

Antecedent surgical resection of tumors is advisable for obtaining better efficacy of immuno-cell therapy, even in advanced cancer patients.

• Authors: Goki Shindo, Takayoshi Endo, Masamitsu Onda, Yoju Miyamoto, Toru Kaneko, Shigenori Goto
• Journal: Cancer immunology, immunotherapy : CII (Cancer Immunol Immunother) Vol. 60 Issue 10 Pg. 1397-403 (Oct 2011) ISSN: 1432-0851 [Electronic] Germany
• PMID: 21638124 (Publication Type: Clinical Trial, Journal Article)

Chemical References

• Cancer Vaccines

Topics

• Adult
• Aged
• Aged, 80 and over
• Cancer Vaccines (immunology)
• Combined Modality Therapy
• Dendritic Cells (immunology, transplantation)
• Female
• Humans
• Immunotherapy (methods)
• Kaplan-Meier Estimate
• Lymphocyte Transfusion
• Lymphocytes (immunology)
• Male
• Middle Aged
• Neoplasms (mortality, therapy)