Abstract | BACKGROUND: OBJECTIVE: We investigated the properties of this delivery modality--lung targeting ceftiofur-Cef-MSs. METHODS: We prepared Cef-MS and investigated drug loading, stability and release characteristics in vitro and studied tissue distribution patterns and potential lung injury in mice. RESULTS: Results showed that the average size and span value are 21.26 μm and 1.07, respectively. Drug loading and loading efficiency were 15.31 and 76.55%, respectively. Cef-MSs were stable in light, heat and humidity, except that agglutinative phenomenon was observed in 90% humidity after 10 days. Cef-MS presented a slower in vitro release pattern compared to ceftiofur. Cef-MS mainly concentrates in lungs after intravenous administration. Furthermore, histopathological studies showed that Cef-MS only induces mild and reversible lung injury and is biologically safe. CONCLUSION: Cef-MS is a promising alternative form with high lung-targeting properties for the treatment of respiratory infections.
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Authors | Zhihui Hao, Baohan Qu, Yanling Wang, Shusheng Tang, Gang Wang, Mei Qiu, Ruili Zhang, Yuanyuan Liu, Xilong Xiao |
Journal | Drug development and industrial pharmacy
(Drug Dev Ind Pharm)
Vol. 37
Issue 12
Pg. 1422-8
(Dec 2011)
ISSN: 1520-5762 [Electronic] England |
PMID | 21635137
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Chemical References |
- Anti-Bacterial Agents
- Cephalosporins
- Drug Carriers
- ceftiofur
- Gelatin
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Topics |
- Animals
- Anti-Bacterial Agents
(administration & dosage, chemistry, pharmacokinetics)
- Cephalosporins
(administration & dosage, chemistry, pharmacokinetics)
- Drug Carriers
(administration & dosage, chemistry, pharmacokinetics)
- Drug Delivery Systems
(methods)
- Female
- Gelatin
(administration & dosage, chemistry, pharmacokinetics)
- Injections, Intravenous
- Lung
(drug effects)
- Male
- Mice
- Microspheres
- Models, Animal
- Particle Size
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