Intact internal dynamics of the neocortex in acutely paralyzed mice.

Abstract

Animals collect sensory information through self-generated movements. Muscle movements drive active feedback of sensory information and determine large parts of the sensory inputs the animal receives; however, little is known about how this active feedback process modulates the ongoing dynamics of the brain. We made electrophysiological recordings from layer 2/3 neurons of the mouse neocortex and compared spontaneous cortical activity in local field potentials and intracellular potential fluctuations between normal and hypomyotonic conditions. We found that pancuronium-induced paralysis did not affect the electrophysiological properties of ongoing cortical activity and its perturbation evoked by visual and tactile stimuli. Thus, internal cortical dynamics are not much affected by active muscle movements, at least, in an acute phase.

• Authors: Genki Minamisawa, Kenta Funayama, Norio Matsuki, Yuji Ikegaya
• Journal: The journal of physiological sciences : JPS (J Physiol Sci) Vol. 61 Issue 4 Pg. 343-8 (Jul 2011) ISSN: 1880-6562 [Electronic] Japan
• PMID: 21633910 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Anesthetics
• Pancuronium

Topics

• Action Potentials (drug effects, physiology)
• Anesthetics (pharmacology)
• Animals
• Blood Pressure (drug effects, physiology)
• Electrophysiological Phenomena (drug effects, physiology)
• Heart Rate (drug effects, radiation effects)
• Male
• Membrane Potentials (drug effects, physiology)
• Mice
• Mice, Inbred ICR
• Neocortex (drug effects, physiology)
• Pancuronium (pharmacology)
• Paralysis (chemically induced, physiopathology)
• Patch-Clamp Techniques
• Photic Stimulation
• Touch (drug effects, physiology)