Prophylactic glycopyrrolate prevents bradycardia after spinal anesthesia for Cesarean section: a randomized, double-blinded, placebo-controlled prospective trial with heart rate variability correlation.

Abstract

STUDY OBJECTIVE:

To determine if prophylactic glycopyrrolate prevents bradycardia after spinal anesthesia.

DESIGN:

Prospective, randomized, double-blinded, placebo-controlled study.

SETTING:

Large university-affiliated community hospital.

PATIENTS:

81 consecutive term parturients (not in active labor) who were scheduled for elective Cesarean section.

INTERVENTIONS:

Parturients received 1.0 to 1.5 L of intravenous Ringer's lactate and either glycopyrrolate 0.4 mg or an equal volume of saline, with caregivers blinded to the immediate sequelae of study drug. Each patient received intrathecal bupivacaine (12 to 14 mg) with morphine sulfate (0.1 to 0.2 mg).

MEASUREMENTS:

Continuous heart rate (HR) and blood pressure monitoring occurred for 20 minutes, with the minimum HR recorded for each 5-minute epoch. Heart rates < 60 beats per minute defined bradycardia. Heart rate variability (HRV) analysis occurred offline.

MAIN RESULTS:

None of 34 patients administered glycopyrrolate and 6 of 35 (17%) patients receiving saline experienced bradycardia (P = 0.02476). Time domain, frequency domain, and nonlinear and embedded spectrum entropy analyses all reflected the decrease in HRV accompanying administration of glycopyrrolate.

CONCLUSION:

Bradycardia after spinal anesthesia occurs commonly. Prophylactic glycopyrrolate may prevent the bradycardia, but not necessarily the hypotension.

• Authors: Dmitri Chamchad, Jay C Horrow, Lev Nakhamchik, John Sauter, Nancy Roberts, Boris Aronzon, Andrew Gerson, Mikhail Medved
• Journal: Journal of clinical anesthesia (J Clin Anesth) Vol. 23 Issue 5 Pg. 361-6 (Aug 2011) ISSN: 1873-4529 [Electronic] United States
• PMID: 21632228 (Publication Type: Journal Article, Randomized Controlled Trial, Research Support, Non-U.S. Gov't)
• Copyright: Copyright © 2011 Elsevier Inc. All rights reserved.

Chemical References

• Adjuvants, Anesthesia
• Anesthetics, Local
• Morphine
• Glycopyrrolate
• Bupivacaine

Topics

• Adjuvants, Anesthesia (therapeutic use)
• Adult
• Anesthesia, Spinal (adverse effects, methods)
• Anesthetics, Local (administration & dosage, adverse effects, therapeutic use)
• Bradycardia (chemically induced, prevention & control)
• Bupivacaine (administration & dosage, adverse effects, therapeutic use)
• Cesarean Section (methods)
• Double-Blind Method
• Female
• Glycopyrrolate (therapeutic use)
• Heart Rate (drug effects)
• Hospitals, University
• Humans
• Hypotension (chemically induced, prevention & control)
• Morphine (administration & dosage, therapeutic use)
• Pregnancy
• Prospective Studies