HOMEPRODUCTSCOMPANYCONTACTFAQResearchDictionaryPharmaSign Up FREE or Login

Reduced expression of ΔΝp63α in cervical squamous cell carcinoma.

AbstractPURPOSE:
As a member of the p53 family, p63 is considered to be an important differentiation regulation transcriptional factor, but the roles of p63 in many epithelial tumourigenesis and metastasis processes are still not clear. This study was designed to investigate the expression of p63 and its isoform in normal tissues and squamous cell cancer tissues of uterine cervix, and its significance in cancer cell differentiation.
METHODS:
The expression of p63 was assessed in cervical tissue and cell lines by immunohistochemistry, RT-PCR and Western Blotting. The relationships between p63 protein, various clinico-pathological features, and the differentiation marker involucrin were analyzed.
RESULTS:
ΔΝp63α is the predominant isoform expressed in cervical epithelial tissues, and it is decreased in moderately or poorly differentiated cervical squamous carcinoma, as well as in the HeLa, SiHa and C33A cervical cancer cell lines. The expression level of ΔΝp63α was positively correlated with that of involucrin in cervical squamous cancer tissue, and the expression of ΔΝp63α is decreased with the degree of tumour invasion.
CONCLUSION:
The decrease of ΔΝp63α in cervical squamous cell cancer appears to be associated with the tumour progression, and ΔΝp63α may be a sensitive marker for cervical squamous cancer differentiation.
AuthorsYing Zhou, Qianqian Xu, Bin Ling, Weihua Xiao, Peishu Liu
JournalClinical and investigative medicine. Medecine clinique et experimentale (Clin Invest Med) Vol. 34 Issue 3 Pg. E184-91 (Jun 01 2011) ISSN: 1488-2353 [Electronic] Canada
PMID21631996 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
Chemical References
  • TP63 protein, human
  • Transcription Factors
  • Tumor Suppressor Proteins
Topics
  • Carcinoma, Squamous Cell (genetics, metabolism)
  • Cell Line
  • Cell Line, Tumor
  • Female
  • Humans
  • Immunoblotting
  • Immunohistochemistry
  • In Vitro Techniques
  • Middle Aged
  • Reverse Transcriptase Polymerase Chain Reaction
  • Transcription Factors (genetics, metabolism)
  • Tumor Suppressor Proteins (genetics, metabolism)
  • Uterine Cervical Neoplasms (genetics, metabolism)

Join CureHunter, for free Research Interface BASIC access!

Take advantage of free CureHunter research engine access to explore the best drug and treatment options for any disease. Find out why thousands of doctors, pharma researchers and patient activists around the world use CureHunter every day.
Realize the full power of the drug-disease research graph!


Choose Username:
Email:
Password:
Verify Password:
Enter Code Shown: