The phenotypic and functional consequences of tumour necrosis factor receptor type 2 expression on CD4(+) FoxP3(+) regulatory T cells.

Abstract

Cytokine receptors expressed by CD4(+)  FoxP3(+) regulatory T cells (Treg cells) not only serve as a phenotypic marker for the identification of this important population of immunosuppressive cells, they also promote the function of Treg cells. CD25, the α-chain of interleukin-2 receptor, is a prototype of such a receptor, which enables Treg cells to be activated by interleukin-2. We and others have found that tumour necrosis factor receptor type 2 (TNFR2) is another important cytokine receptor preferentially expressed by Treg cells with important phenotypic and functional roles. TNFR2 is preferentially expressed by highly functional human and mouse Treg cells, and mediates the activating effect of TNF on Treg cells. We review here the studies of the regulation of expression of TNFR2 on functional Treg cells as well as on CD4(+)  FoxP3(-) effector T cells (Teff cells). We document the critical role of this receptor in the activation, proliferative expansion and survival of Treg cells. The contribution of TNFR2 expression on Treg and Teff cells to the beneficial and detrimental effects of anti-TNF treatment in autoimmune disorders will also be discussed.

• Authors: Xin Chen, Joost J Oppenheim
• Journal: Immunology (Immunology) Vol. 133 Issue 4 Pg. 426-33 (Aug 2011) ISSN: 1365-2567 [Electronic] England
• PMID: 21631498 (Publication Type: Journal Article, Research Support, N.I.H., Extramural, Research Support, N.I.H., Intramural, Review)
• Copyright: © 2011 The Authors. Immunology © 2011 Blackwell Publishing Ltd.

Chemical References

• CD4 Antigens
• Forkhead Transcription Factors
• Receptors, Tumor Necrosis Factor, Type II

Topics

• Animals
• CD4 Antigens (immunology)
• Forkhead Transcription Factors (immunology)
• Humans
• Phenotype
• Receptors, Tumor Necrosis Factor, Type II (biosynthesis, immunology)
• T-Lymphocytes, Regulatory (cytology, immunology)