Abstract | BACKGROUND: Overexposure to carbon disulfide (CS(2) ) has been associated with an increase in coronary heart disease, but the mechanisms mediating this effect remain unclear. We aimed to examine the relationship between CS(2) exposure and oxidative stress markers, in order to clarify the oxidative mechanisms involved in CS(2) -induced atherosclerosis. METHODS: RESULTS: The workers exposed to CS(2) had significantly higher MDA levels and lower SOD levels than the controls. The average MDA levels were 776 ± 268.2 (240-1,220) in the high exposure (≥10 ppm; n = 38), 751.6 ± 274 (170-1,320) in the low exposure (<10 ppm; n = 51), and 550.4 ± 199 (115-1,050) mM in the control group (n = 111). The average SOD levels were 36.5 ± 38.8 (0-223.5), 39.3 ± 38.8 (0-160), and 58.8 ± 60.8 (5.25, 400) U/ml in the high exposure-, low exposure-, and control group, respectively. MDA level increased significantly at a cumulative CS(2) exposure of over 60 ppm-years. Dyslipoproteinemia was borderline significantly associated with CS(2) exposure and MDA level. CONCLUSIONS: These results indicate that CS(2) exposure can induce oxidative stress as well as reduce the levels of antioxidative enzymes, and that a cumulative exposure level of 60 ppm-years may be a threshold value for the oxidative and the antioxidant response. Am. J. Ind. Med. 54:637-645, 2011. © 2011 Wiley-Liss, Inc.
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Authors | Jiin-Chyuan John Luo, Tung-Sheng Shih, Cheng-Ping Chang, Chin-Chang Huang |
Journal | American journal of industrial medicine
(Am J Ind Med)
Vol. 54
Issue 8
Pg. 637-45
(Aug 2011)
ISSN: 1097-0274 [Electronic] United States |
PMID | 21630299
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Copyright | Copyright © 2011 Wiley-Liss, Inc. |
Chemical References |
- Air Pollutants, Occupational
- Antioxidants
- Biomarkers
- Triglycerides
- Malondialdehyde
- Cellulose
- Cholesterol
- rayon, purified
- Catalase
- Glutathione Peroxidase
- Superoxide Dismutase
- Carbon Disulfide
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Topics |
- Adult
- Air Pollutants, Occupational
(toxicity)
- Antioxidants
(analysis)
- Atherosclerosis
(blood, chemically induced, enzymology)
- Biomarkers
(blood)
- Carbon Disulfide
(toxicity)
- Catalase
(blood)
- Cellulose
- Cholesterol
(blood)
- Cross-Sectional Studies
- Female
- Glutathione Peroxidase
(blood)
- Humans
- Male
- Malondialdehyde
(blood)
- Middle Aged
- Occupational Diseases
(blood, chemically induced, enzymology)
- Occupational Exposure
(adverse effects)
- Oxidative Stress
- Superoxide Dismutase
(blood)
- Taiwan
- Textiles
- Triglycerides
(blood)
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