Abstract |
We present a case of life-threatening Epstein-Barr virus (EBV)-associated hemophagocytic lymphohistiocytosis (HLH) with severe hepatitis that was successfully treated by allogeneic stem cell transplantation from an unrelated donor. A 26-year-old woman was admitted to hospital with a high fever and liver dysfunction. Laboratory tests, including bone marrow aspiration, revealed severe HLH that occurred after EBV infection. High-dose methylprednisolone and etoposide therapy did not control the disease. We could control the HLH, but the EBV viremia continued following the CHOPE ( cyclophosphamide, doxorubicin, vincristine, prednisone, and etoposide) chemotherapy regimen. Therefore, the patient underwent allogeneic bone marrow transplantation from an HLA-matched, unrelated donor. The patient has remained in good condition without disease recurrence for 2 years after bone marrow transplantation. Although there is no consensus regarding allogeneic stem cell transplantation for EBV-HLH, it is the treatment of choice for aggressive EBV-HLH when the patient is refractory to intensive chemotherapy.
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Authors | Akane Kunitomi, Hiroshi Kimura, Yoshinori Ito, Kazuyuki Naitoh, Nobuhiko Noda, Hiroatsu Iida, Hiroshi Sao |
Journal | Journal of clinical and experimental hematopathology : JCEH
(J Clin Exp Hematop)
Vol. 51
Issue 1
Pg. 57-61
( 2011)
ISSN: 1880-9952 [Electronic] Japan |
PMID | 21628862
(Publication Type: Case Reports, Journal Article)
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Topics |
- Adult
- Bone Marrow Transplantation
- Epstein-Barr Virus Infections
(complications, surgery)
- Female
- Hematopoietic Stem Cell Transplantation
- Humans
- In Situ Hybridization
- Lymphohistiocytosis, Hemophagocytic
(surgery, virology)
- Polymerase Chain Reaction
- Viremia
(surgery)
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