Abstract | BACKGROUND: OBJECTIVES: METHODS: Participants provided blood samples either by mail (blood drawn at local health care provider near home) or at the work site (blood drawn by research staff on-site) and completed a health and work history questionnaire at the time of blood draw. Exposure to SHS was measured by plasma cotinine concentrations. We used multivariate regression analyses to assess the associations between levels of cotinine and inflammatory markers. RESULTS: The median cotinine level was 0.10 ng/mL (interquartile range, 0.04-0.23 ng/mL). The odds ratios of elevated hs-CRP (above highest CRP tertile, 1.5 mg/L) were 2.85 [95% confidence interval (CI), 1.03-7.89] for the high- cotinine group (> 0.215 ng/mL) and 2.80 (95% CI, 1.11-7.10) for the moderate- cotinine group (0.05-0.215 ng/mL), compared with the low- cotinine group (< 0.05 ng/mL), adjusting for age, sex, race, educational level, obesity, previous smoking history, job title, and medical history. Plasma cotinine levels were not associated with IL-6 or sICAM-1. CONCLUSIONS: SHS exposure, as assessed by plasma cotinine, was positively associated with hs-CRP in this group of blue-collar workers. The strength of the association with hs-CRP depended on the cut points selected for analysis.
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Authors | Yueh-Hsiu Mathilda Chiu, Donna Spiegelman, Douglas W Dockery, Eric Garshick, S Katharine Hammond, Thomas J Smith, Jaime E Hart, Francine Laden |
Journal | Environmental health perspectives
(Environ Health Perspect)
Vol. 119
Issue 9
Pg. 1294-300
(Sep 2011)
ISSN: 1552-9924 [Electronic] United States |
PMID | 21628108
(Publication Type: Journal Article, Research Support, N.I.H., Extramural, Research Support, Non-U.S. Gov't)
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Chemical References |
- Biomarkers
- Interleukin-6
- Tobacco Smoke Pollution
- Intercellular Adhesion Molecule-1
- C-Reactive Protein
- Cotinine
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Topics |
- Biomarkers
(blood)
- C-Reactive Protein
(analysis)
- Cotinine
(blood, immunology)
- Female
- Humans
- Inflammation
(blood)
- Intercellular Adhesion Molecule-1
(blood)
- Interleukin-6
(blood)
- Male
- Middle Aged
- Motor Vehicles
- Multivariate Analysis
- Occupational Exposure
- Regression Analysis
- Surveys and Questionnaires
- Tobacco Smoke Pollution
- United States
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