The use of a polymeric sealant for prevention of posttransplantation lymphocele.

Abstract

The aim of this study was to investigate the effectiveness of a synthetic polyethy lenglycol (PEG) sealant to prevent lymphocele formation after kidney transplantation. The examined group consisted of 719 recipients including 294 female and 425 male who were immunosuppressed with a calcineurin inhibitor, plus basiliximab since 1999, and with mycophenolate mofetil in addition since 2000. We retrospectively analyzed the incidence of lymphoceles among 545 recipients operated between November 1999 and November 2007 (group I), 93 recipients at standard risk for lymphocele transplanted between December 2007 and December 2009 (group II) in whom we performed only routine ligation of the lymphatic vessels during preparation of the graft, and 31 patients also transplanted between December 2007 and December 2009 who were at higher risk for lymphocele (group III) and underwent an off-label application of the PEG sealant. There was no significant difference in patient demographic features among the groups. In total, 21 group I, patients (3.5%) developed symptoms of a lymphocele that required ≥1 corrective procedures, whereas only 1 group II patient (1.07%) developed a lymphocele and no group III patient evidenced a symptomatic lymphocele. No adverse events were observed among group III patients after PEG sealant application. although the preliminary results are interesting, a prospective randomized study is required to assess the cost-effectiveness of PEG sealant to prevent lymphocele formation.

• Authors: L Berardinelli, M Raiteri, A Pasciucco, M Carini
• Journal: Transplantation proceedings (Transplant Proc) Vol. 43 Issue 4 Pg. 1072-3 (May 2011) ISSN: 1873-2623 [Electronic] United States
• PMID: 21620056 (Publication Type: Journal Article)
• Copyright: Copyright © 2011 Elsevier Inc. All rights reserved.

Chemical References

• Antibodies, Monoclonal
• Calcineurin Inhibitors
• Immunosuppressive Agents
• Recombinant Fusion Proteins
• Tissue Adhesives
• Polyethylene Glycols
• Basiliximab
• Mycophenolic Acid

Topics

• Adolescent
• Adult
• Aged
• Antibodies, Monoclonal (therapeutic use)
• Basiliximab
• Calcineurin Inhibitors
• Child
• Child, Preschool
• Drug Therapy, Combination
• Female
• Graft Survival
• Humans
• Immunosuppressive Agents (therapeutic use)
• Infant
• Italy
• Kaplan-Meier Estimate
• Kidney Transplantation (adverse effects, mortality)
• Lymphocele (etiology, mortality, prevention & control)
• Male
• Middle Aged
• Mycophenolic Acid (analogs & derivatives, therapeutic use)
• Polyethylene Glycols (therapeutic use)
• Recombinant Fusion Proteins (therapeutic use)
• Retrospective Studies
• Survival Rate
• Time Factors
• Tissue Adhesives (therapeutic use)
• Treatment Outcome
• Young Adult