Recurrent intrahepatic pigmented stones after liver transplantation in a patient with hemoglobin SC disease: case report and review of the literature.

Abstract

Patients with hemoglobinopathies may have hepatic involvement, which if severe, can lead to chronic liver disease and a need for liver transplant. Here, we present a case of a 16-yr-old female adolescent who presented to our center with hemoglobin SC disease, obstructive jaundice because of pigmented intrahepatic biliary stones, and progressive liver disease. She underwent a successful liver transplant but a few years later, she developed recurrent cholangitis and graft dysfunction because of recurrent intrahepatic biliary stones. Recurrent formation of intrahepatic stones after liver transplant is a rare and severe complication in patients with hemoglobinopathies. We recommend hypertransfusion therapy and surveillance imaging studies after liver transplant for early detection and prevention of this complication.

• Authors: Juli Tomaino, Tara Keegan, Nanda Kerkar, Marcelo Facciuto, Tamir Miloh, Bachir Taouli, Anne Hurlet, Joshua Weintraub, Divyesh Sejpal, Ronen Arnon
• Journal: Pediatric transplantation (Pediatr Transplant) Vol. 15 Issue 5 Pg. 519-24 (Aug 2011) ISSN: 1399-3046 [Electronic] Denmark
• PMID: 21615648 (Publication Type: Case Reports, Journal Article)
• Copyright: © 2011 John Wiley & Sons A/S.

Topics

• Adolescent
• Calculi (diagnosis, etiology)
• Cholangiopancreatography, Endoscopic Retrograde (methods)
• Cholangitis, Sclerosing (complications, etiology)
• Female
• Hemoglobin SC Disease (complications, therapy)
• Humans
• Liver Failure (therapy)
• Liver Transplantation (adverse effects, methods)
• Pigmentation
• Postoperative Complications
• Recurrence
• Treatment Outcome