Abstract | OBJECTIVE: METHODS: Forty-six eyes of 33 patients with clinically significant macular edema (CSME) caused by diabetic retinopathy were randomized to either SDM (810?nm) laser or the conventional double-frequency Nd:YAG (532?nm) laser. Primary outcome measures were: change in the central macular thickness as measured by optical coherence tomography (OCT) and change in macular retinal sensitivity measured using multifocal electroretinography (MfERG). Secondary outcomes were: change in best corrected visual acuity (BCVA) and contrast sensitivity. RESULTS: The group was divided in half, with 23 eyes assigned to SDM laser and 23 eyes assigned to double-frequency Nd:YAG laser. Mean follow-up period was 6 months. No statistically significant difference was noted in either the primary or the secondary outcome measures between the two groups. Macular thickness decreased from the baseline measures of 298.5?49.3 and 312.9?45.8??m to 274.9?62.9 and 286.7?32.8??m in the SDM laser and Nd:YAG laser groups, respectively. On MfERG, P1 implicit wave time delay at baseline changed from 46.27?4.9 to 45.27?3.4?ms in the SDM group and from 46.55?4.9 to 45.27?4.1?ms in the Nd:YAG group. MfERG recordings of 18 of the 23 eyes treated with double-frequency Nd:YAG laser showed areas of signal void as compared to 4 eyes treated with the SDM laser. CONCLUSIONS:
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Authors | Pradeep Venkatesh, Rajesh Ramanjulu, Rajvardhan Azad, Rajpal Vohra, Satpal Garg |
Journal | Photomedicine and laser surgery
(Photomed Laser Surg)
Vol. 29
Issue 11
Pg. 727-33
(Nov 2011)
ISSN: 1557-8550 [Electronic] United States |
PMID | 21612513
(Publication Type: Comparative Study, Journal Article, Randomized Controlled Trial)
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Topics |
- Diabetic Retinopathy
(physiopathology, radiotherapy)
- Electroretinography
- Humans
- Lasers, Semiconductor
(therapeutic use)
- Lasers, Solid-State
(therapeutic use)
- Macular Edema
(physiopathology, radiotherapy)
- Prospective Studies
- Tomography, Optical Coherence
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