Abstract | BACKGROUND: AIM: To find out whether aminoguanidine (AG) protects against CP-induced oxidative stress and renal damage. METHOD: RESULTS: Pretreatment with AG attenuated CP-induced renal damage histologically. Pretreatment with AG prevented CP-induced lipid peroxidation, protein oxidation, depletion of reduced GSH, and loss of activities of the antioxidant enzymes including GPx, catalase, and GSTase and also MPO activity. CONCLUSION: The results of the present study reveal that AG can prevent CP-induced renal damage by inhibiting oxidative stress. Thus, AG may be useful for prevention of the nephrotoxicity of CP.
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Authors | Premila Abraham, Suganthy Rabi |
Journal | Redox report : communications in free radical research
(Redox Rep)
Vol. 16
Issue 1
Pg. 8-14
( 2011)
ISSN: 1743-2928 [Electronic] England |
PMID | 21605493
(Publication Type: Journal Article)
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Chemical References |
- Guanidines
- Reactive Oxygen Species
- Malondialdehyde
- Cyclophosphamide
- Catalase
- Peroxidase
- pimagedine
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Topics |
- Animals
- Catalase
(metabolism)
- Cyclophosphamide
(adverse effects)
- Guanidines
(pharmacology, therapeutic use)
- Kidney
(drug effects, enzymology, pathology)
- Kidney Diseases
(chemically induced, drug therapy)
- Male
- Malondialdehyde
(metabolism)
- Models, Animal
- Oxidative Stress
- Peroxidase
(metabolism)
- Pilot Projects
- Rats
- Rats, Wistar
- Reactive Oxygen Species
(metabolism)
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