[Clinical value of CD64 expression in adults with measles complicating bacterial pneumonia].

Abstract

OBJECTIVE:

To study the clinical value of expression of peripheral blood neutrophil CD64 in adults with measles complicating pneumonia.

METHODS:

106 patients were divided into two groups by clinical manifestation and bacteria study: measles complicating bacterial pneumonia group and measles complicating viral pneumonia, using flow cytometry determination of CD64, C-reactive protein (CRP) and white blood cell (WBC) count.

RESULTS:

The expression of CD64 in the bacterial pneumonia group with eruptive stage was (32.15 +/- 11.07) MFI, which was significantly higher than that in the group of with recovery stage (10.6 +/- 3.23) MFI (P < 0.01) and viral pneumonia (9.55 +/- 3.48) MFI (P < 0.01). These markers were considered positive if CD64 > or = 8.5 MFI, CRP > or = 10 mg/L and WBC > or = 9.05 x 10(9)/L. Their sensitivity was 78.12%, 80.48% and 59.37%. Their specificity was 76.19% ,67.67% and 64.28%. Their accuracy rate was 77.35%, 74.52%, 61.32%; CD64 has a positive relationship with CRP.

CONCLUSION:

Compared to CRP, expression of peripheral blood neutrophil CD64 can be a better marker in the early diagnosis of patients with measles complicating bacterial pneumonia and as one of the indicators of disease conditions.

• Authors: Jia-Liang Tang, Wen-Fang Xu, Yong Wu
• Journal: Zhonghua shi yan he lin chuang bing du xue za zhi = Zhonghua shiyan he linchuang bingduxue zazhi = Chinese journal of experimental and clinical virology (Zhonghua Shi Yan He Lin Chuang Bing Du Xue Za Zhi) Vol. 24 Issue 6 Pg. 445-7 (Dec 2010) ISSN: 1003-9279 [Print] China
• PMID: 21604572 (Publication Type: English Abstract, Journal Article)

Chemical References

• Biomarkers
• Receptors, IgG
• C-Reactive Protein

Topics

• Adult
• Biomarkers (blood, metabolism)
• C-Reactive Protein (metabolism)
• Female
• Humans
• Leukocyte Count (methods)
• Male
• Measles (blood, immunology, microbiology)
• Pneumonia, Bacterial (blood, immunology, virology)
• Receptors, IgG (biosynthesis, blood, immunology)