[The correlation between hyperinsulinemia and pulse wave velocity].

Abstract

OBJECTIVE:

To study the correlation between hyperinsulinemia (HIns) and arteriosclerosis in one community in Beijing.

METHODS:

Subjects who received arteriosclerosis screening in physical examination annually were studied. All subjects were received 75g oral glucose tolerance test (OGTT) to evaluate glucose metabolic level, and brachial-ankle pulse wave velocity (baPWV) examination to evaluate arteriosclerosis. The correlation between hyperinsulinemia and pulse wave velocity was analyzed.

RESULTS:

Among all the 1046 subjects under investigation, baPWV of subjects with HIns was higher than subjects with normoinsulinemic (NIns) in different glucose metabolism status [normal glucose tolerance, (1381.2 ± 280.8) cm/s vs (1280.3 ± 218.7) cm/s; imparied glucose regulation, (1557.5 ± 319.3) cm/s vs (1474.7 ± 305.1) cm/s; diabetes, (1764.3 ± 476.6) cm/s vs (1664.2 ± 374.6) cm/s], especially in subjects with normal glucose tolerance (P < 0.01). The prevalence of cardiovascular risk factors in subjects with HIns was much higher than subjects with NIns (P < 0.01). Multiple logistic regression analysis showed that hyperinsulinemia was the risk factor of arteriosclerosis, and the OR (95%CI) of subjects with HIns was 1.91 (1.169 - 3.105, P < 0.01) as compared to the subjects with NIns.

CONCLUSION:

The subjects with HIns suffered from much more metabolic risk factors than NIns. Hyperinsulinemia that closely correlated with baPWV was a risk factor of arteriosclerosis.

• Authors: Fu-Sheng Fang, Hui Tian, Chun-Lin Li, Min-Yan Liu, Xin-Yu Miao, Xiao-Ling Cheng
• Journal: Zhonghua nei ke za zhi (Zhonghua Nei Ke Za Zhi) Vol. 50 Issue 4 Pg. 299-302 (Apr 2011) ISSN: 0578-1426 [Print] China
• PMID: 21600148 (Publication Type: English Abstract, Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Blood Glucose

Topics

• Adult
• Arteriosclerosis (physiopathology)
• Blood Glucose (metabolism)
• Female
• Glucose Tolerance Test
• Heart Rate
• Humans
• Hyperinsulinism (physiopathology)
• Male
• Middle Aged
• Pulse
• Risk Factors