Abstract | OBJECTIVE: PATIENTS AND METHODS: Neonates with gastroschisis treated at a tertiary children's hospital over a 10-year period were initially categorized into groups based on the lowest serum albumin measurement during the first 7 days of life. Based on preliminary analysis, patients with serum albumin <1.5 g/dL were considered to have early severe hypoalbuminemia. Intestinal failure was defined as inability of the patient to wean from parenteral nutrition (PN) during the initial hospital admission, thus requiring home PN. Logistic regression modeling was performed to adjust for sex, gestational age, birth weight, and concomitant intestinal complications. RESULTS: CONCLUSIONS: Early severe hypoalbuminemia appears to be an independent risk factor for long-term intestinal compromise rather than merely an indicator of overall illness. Further interventional studies are needed to determine whether clinical protocols utilizing judicious fluid administration, exogenous albumin, and early enteral feeding can improve clinical outcomes in gastroschisis.
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Authors | Christopher W Snyder, Joseph R Biggio, Donna T Bartle, Keith E Georgeson, Oliver J Muensterer |
Journal | Pediatric surgery international
(Pediatr Surg Int)
Vol. 27
Issue 11
Pg. 1155-8
(Nov 2011)
ISSN: 1437-9813 [Electronic] Germany |
PMID | 21598041
(Publication Type: Comparative Study, Journal Article)
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Topics |
- Alabama
(epidemiology)
- Edema
(complications, epidemiology)
- Female
- Follow-Up Studies
- Gastroschisis
(complications, epidemiology)
- Humans
- Hypoalbuminemia
(epidemiology, etiology)
- Ileus
(complications, epidemiology)
- Incidence
- Infant, Newborn
- Male
- Retrospective Studies
- Risk Factors
- Severity of Illness Index
- Survival Rate
(trends)
- Time Factors
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